I take mine on Saturday nights. I do work on Sundays, but my workload is lighter most of the time. I have not experieced terrible side effects from MTX, other than being a little bit tired on Sundays. MTX is working really well for me.

I take mine on Tuesdays, mostly because that's when i have rheum appts. Haha. I don't have any real side effects unless I take on empty stomach and laod up the coffee. The first few weeks I sometimes felt a bit queasy. I take it in the morning and go to work without problems. Everyone is different, so I would pick the day based on workload.

Hi and welcome but sorry that you had to find us. I take mine on Friday to recover on the weekend. The side effects are not bad now. However, the first time I was in bed all weekend with rash, bumps in my mouth, fatique,nausea, etc. That does not happen now. I recently had to stop for 3 weeks and when I restarted it was not bad at all. But I do have a terrible flare up this weekend. Good luck.

I take mine on sunday, because i feel so much better the next day.
But, since a lot of people experience side effect (particularily in the beginning) I would take it in the evening and pick a day that allows you the most rest the next day.

I take mine on Friday nights. I sometimes feel tired out on Sundays, or a bit queasy, but it's not too bad.

Sunday night just before bed after a meal with a large glass of water. I don't have side effects this way. I used to split up my dose on Sunday with half in the morning and half at night. But, then I decided it just made Sundays terrible with a bit of nausea all day. So, I ditched that plan and take 5 pills at once just before bed and have no problems.

Make sure you are taking folic acid to counter other side effects.

Good luck! But, don't expect quick results. Be patient and take it easy until you find the right "drug cocktail".

I have taken mine probably on every day of week through out this last year as I have had to stop/start the drug repeatedly due to to infections, liver issues and medical procedures, but I found for me that to take it earlier in the week worked best because it did make me really tired and gave me minor stomach discomfort tll I adjusted to it. I wanted to have the most energy and the least RA symptoms on the weekend when my family would want me to be more active with them. I am a stay at home mom so for me this worked the best. You are probably going ot have to sort it out b y trial and error as for what works b est for you. If you have a problem with the day you start it then just extend your taking it by one day at a time until you get to the day you prefer. That way you dont' disrupt the schedule and your bodies need for the medication by holding it off too many days. It seems to me tha for most people you eventually adjust to any side affects unless they are so bad that you can't take it at all. Remember it will take a long time to see any benefit from this drug but stay on it and wait and the pay off usually is good if you don't have side affects too bad.

I work Monday through Friday So I was advised to take it Friday after work just in case there are side effects during the weekend so I can be at work on Monday. I started taking it about two months ago and every weekend is different. Sometimes I'm okay. Sometimes I'm nauseated. Sometimes I have to make sure I don't do hardly anything because if I do I get really weak and sweaty and clammy and can't do anything but lie there. It's never the same therefore I think it is a good thing to do two days before u have to do anything and I figured out that if I'm doing anything and I start getting tired and clammy I know I MUST sit or lay down. It's usually about ten to fifteen min of doing something when that happens but I don't like it so I don't let it happen. Lol. I haven't had to call in on any Mondays yet though so that's good. Good luck!!

I take mine on Saturday nights and am pretty useless on Sundays. I call it the MTX hangover . . . Rundown, stomach pain/nausea and fatigue. Much better on Monday.

I will be switching to Injectable in June.

It is worth it for me. It started helping within 3 weeks.

I'm not great, but I am MUCH better. SSZ and MTX are my cocktail!

Thanks all! Your replies are definitely helpful. It seems like I need to figure out which days I can "spare" in case of side effects. I am not working atm, but I have hopes of returning to work at some point in the near future, so I will have to factor that in, I guess.
It sucks to be planning which days are most convenient for me to feel like crap!

I take mine on Sunday nights. I have had no problems with MTXS, except for feeling more tired than usual for a couple of days for the first month or so. I take 25mg (i.e. ten tablets) orally and the following day, I take 10mg Folic Acid. I make sure I drink plenty of water the day before and on the day I take JTC. I also try to have a proper meal for dinner.
good luck

I take MTX on Mondays. The only side effect I experienced was some strands of hair falling out - but just a few so it never concerned me. Othewise no other side effects at all. I am two pills per week now, but at one point was on 5 pills per week. I take an Enbrel shot on Thursdays.

Just got official ok to start the mtx this week. I am still not sure which I want to start on. I am leaning toward Thursday night, but we'll see.

Thanks again for all the replies. It's really helped!

You will find out yourself what day works for you. It takes a while to build up in the system too. Lots of ideas on here about what to do and people affected differently. I am always grateful to whoever posted some years back about taking Vit C the day before and on the day as that definitely seems to help me. When I travel especially I get slack and soon notice the difference. But you may be different.

Also postings about whether to take all at once (if pills) or spread over the day. Have tried both way and now back to taking mine all in one go at night and sleeping until I wake up. I have that luxury as no longer working.

Another member who has effectively left the site but with whom I am still in contact plays about with her dose as mtx makes her so tired. After a while both she and I find we are able to reduce it. I also sometimes spread the time between doses. It just depends how I am going.

It takes a long time to really work out what things help and what doesnt for you. But great to be proactive and getting ideas here are part of that. Hope mtx works for you. I have been on it twice as after 18 months had to come off because of elevated liver enzymes. Girl I know here was even hospitalised because of this issue and then put back on it with no further problems. After about a year off and failure of alternatives I went back on it and three years down the track holding steady with the universal experience of up and down periods/flares etc.

No right way I would suggest. But I do really recommend that Vit C - at least 1000mg and as Angelpuss says lots of water. Makes sense really - toxic substance, albeit helpful, keep hydrated.

Friday nights so I have the weekend to recover. I work Monday thru Friday. I am a bit nauseated and fatigued the following two days.
Hope u find what works for u!
Xoxo MLC.