250, wow. i take 150 effexor and i'm flying. I had the weight gain with Mirtazapine [take at night with the Effexor in the morning], so I stopped the Mirtazapine. Maybe you could try the combo. If you find anything else that works better than the Effexor, let me know. The combo works good for depression but you get the weight gain with the Mirtaz.
Lisa

Antideppressants never helped me that much. i've tried them all. I am currently taking celexa and it does seem to help better than the others.

I take 80 mg of celexa and it makes a huge difference.
Susan NC

I personally think you should discuss this with your physician. Everyone reacts differently to medications and particularly to mood modifiers of any sort. Just a suggestion. :-)

I take 10mg of Lexapro. I didn't have weight gain until I was upted to 15 mg. I began to feel better and was put down to 10 mg., but the weight is challenging to loose. Antidepressents don't work up to their potential without active involvement with a councelor.

Sandr58: I was taking Lexapro with no weight gain, just had a reallly hard time getting off of it. I am taking Cymbalta, also helps with leg pain from the MS. No weight gain, as a matter of fact I have lost 17 lbs.! Dont know if it is at all related, but WHO CARES! Doctors dont really say much about antidepressants, they just prescribe whatever they think they want u to try! I heard Wellbutrin works really good for depression, I tried it, it made me very angry! I tried for 2 months and then I stopped before my family kicked me out of the house! Good luck

I take Wellbrutin! Great so far...been on it a year, slows the smoking down too. I drink milkshakes am, noon and a good dinner....In all truth I SHOULD weigh about 275 with all the milk shakes, but I am 5'6 and weigh 137.....used to be 145 prior to wellbrutin.

I heard Cymbalta really perks ya up, my damn shrink wont give it to me...he says "I'm the shrink here...I asked "Are you sure"????

first off,i can totally relate to this one.i've been on many med's for about 25 yrs.right now i'm taking celexa & welbrutrin.valium started out for spasticity,but i lucked out with the anxiety.

some dr's overload you with med's,some don't want to consider changes.or consider changing the ones you're taking that can be driving you up the wall with side effect's.

the whole key is to find the right one for you.which is not always easy to do.my current doctor of 5 yrs.is very strick on med's.when we started out he kept asking me have you ever tried this one or that one.sometimes if a primary family member has symptom's close to your's,that med might work.

believe me i'm not trying to be a dr.the only thing you can do is be persistant with the physciatrist.it took me 4 month's to get off two that made me horrible.he finally agreed.

i wish you all the best.we don't like to take to many med's,but ya know what if it help's us to function better in daily living,i'm for it.
good luck to all of you!!!!!!!

i forgot to check the box to keep hearing about this problem.maybe i need a med change.only kidding lol

I took Zoloft for a few years and it lost its effectiveness. Switched to Effexor and had to up the dose after the first few months. Now I need to call my doc and see what else I can try I am very depressed and struggle with anxiety.

I tok Zoloft for a while and I remember my doc asking me one time one of the sources of my anxiety and I said it was over having to call and get refills on stupid things like Zoloft. I ended up forgetting to take it a lot when I started singing - then one day I threw it in the garbage. I refuse to take anything other than my MS stuff.

Note tho I also had to tell myself that it is natural to feel bad sometimes and to just sit down and cry - I don't think there is supposed to be a pill for that. Exercise and dieting have changed my life.

Antidepressants, most notably the SSRIs, vary in effectiveness from person to person. I've been on Prozac, Celexa, Zoloft, and currently 10mg of Lexapro. I think taking an antidepressant and being in therapy -- especially cognitive behavioral therapy -- is the most effective combination for managing depression. Also, drug therapy takes time -- at least 6 to 8 weeks to feel full benefits.

Talk with your physician about a possible med switch, and be honest about how you're feeling. Consider joining a support group or going into short-term therapy, and above all, don't give up!

-Karen

Maybe Cymbalta. It is one of the newer ones and supposedly has a pain relief aspect to it al well.

romika, what does the cognitive behavioral therapy do? What does it help you with ?I mean,what is it like?