Side effects?

Loss of brain cells and really large boobs. :)

Interesting...

I didn't see it listed on cliniclatrials.gov yet, but they're not all that current (unless I missed it)

I just googled VERY briefly and didn't see your trial. I saw a 12 week with IDX184 + Ribavirin +Ifn. Can you confirm that it has IDX184 AND Telaprevir but no Riba???

Also, do you have any idea what your IL28B is?
ANd where are you doing this?

Thanks...

I was told no interferon, no peg injections, just pills. Triple tx Ribavirin, Telaprevin and whatever the IDX184 IS (made by Idenix pharmaceuticals.) It's a phase 2b in Houston at the Texas Liver Specialists. There are two others on the list that have this Dr. and think highly of him... Dr. Joe Gallati.
I don't know what my IL28B is.

I want the last side effect

If you need to get into a trial to get treatment, and you want treatment, go for it. You may not have many/any choices.

hmmm...open label. I found a reference to a double blind study w/your doctor and IDX184 but no additional info.

I have heard of your doctor and have no doubt he's very good. The trials are sponsored by the pharmaceutical companies who in turn pay your doctor to conduct them so the protocol, etc are coming from pharma and not your doctor.

It sounds like a pretty potent arsenal. We know a lot about Ribavirin and Telaprevir (Incivek) and the addition of DX 184 sounds good to me!
Phase II is a decent phase to jump in on as well.
I have pasted some info I found about DX184 below.
I wish you all the luck there is bagolady!
http://www.idenix.com/hcv/drug.html

DX184, a Nucleoside/tide Polymerase Inhibitor
IDX184 is Idenixs unpartnered lead product candidate for the treatment of Hepatitis C virus (HCV). It is a once-daily, oral HCV nucleotide polymerase inhibitor based on Idenixs proprietary liver-targeting technology. This technology enables the formation of high levels of nucleoside triphosphate, the active form of the drug, in the liver to potentially maximize drug efficacy and limit systemic side effects with low, once-daily dosing.
IDX184 has exhibited a high barrier to resistance and broad genotypic coverage in in vitro studies, has demonstrated potent antiviral activity, and was generally safe and well tolerated in a Phase IIa 14-day study. This clinical trial evaluated IDX184 in combination with pegylated interferon (PegIFN) and ribavirin (RBV) in treatment-nave HCV genotype 1-infected patients.
In July 2011, the Company initiated enrollment of treatment-nave genotype 1 HCV-infected patients into a randomized, double-blind, parallel group phase IIb clinical trial of IDX184. The study features two treatment arms, either 50 mg or 100 mg of IDX184 administered once-daily for 12 weeks, each arm in combination with pegylated interferon and ribavirin (PegIFN/RBV). Study objectives include safety and tolerability, and antiviral activity endpoints.
In January 2012, the Company reported an interim analysis from this study of the first 31 patients who completed 28 days of treatment demonstrating favorable safety and antiviral activity. At 12 weeks in an intent-to-treat analysis, the Complete Early Virologic Response (cEVR < 25 IU/mL) was 93% for the 100 mg IDX184 arm (n=15) and 81% for the 50 mg IDX184 arm (n=16) of the study. The side effect profile of the combined therapy has remained consistent with the known safety profile for pegylated interferon and ribavirin.

The info I posted did use INF but it looks like your trial is excluding it. Nice!!

Joe, your url said it was a invalid one.

My thoughts on the trials without Interferon are this:

#1. We all know that the shots are what makes us feel like we have the flu, and for good reason. Interferon is what our bodies naturally make when we get the flu, so it really isn't a drug. It's a naturally occuring substance in our bodies that boosts our immune system. I know it's hard to embrace and welcome something when it's making you feel so crappy. For instance, when we get a fever, we immeditately want it gone because it's making us feel uncomfortable, when in fact, that's our bodies way of fighting whatever bug we've got...burning it out is destroying the harmful thing that has snuck into your body. Interferon is used for many more illnesses other than just Hep C. It's been used for various kinds of Cancer, and other very nasty viral bugs that are out there. Over all, it's a good thing. I'm trying to welcome shot day because I know that my immune system is getting a boost for several days, and that I will get a break from the flu like symptoms in a few days.

2. Ribavarin: This drug is what is not allowing the virus to replicate anymore. It's what causes some of the nastier side effects. Many people have to have the dosage reduced. If I was looking for gentler way to do treatment, I would look for a trial that is without Riba. Although I don't think there is one because we need the Riba to stop the virus from mutating and replicating itself.

3. The Incevik: I think this drug is the actual killer of the virus and despite what they say, it doesn't tolerate many other chemicals to be used with it. Certian toothpastes for 1. Use it and get a flaming, hot, sore, mouth! Eat too much sugar, here comes the rash from hell, etc. I think they will find that rather than cause all these side effects by itself, they will find that Incevik in combination with certain chemicals and even certain foods cause the problems.

Overall, I'm pretty okay with the treatment I'm on, even though we're still looking at only 79% cure rate. That new drug added to the trial...who knows, it might just be the magic bullet they have been looking for. All I know is that they better come up with something quick. Just heard on the news last night that they are urging baby boomers to get tested. They said they think there's another 200,000 people who will show up with the virus. People who work Hep C patients (docs etc) now are thinking that another 3 million are going to show up in the US alone! All I know is that they need to test everyone, not just the baby boomers, and the public is going to go crazy for a cure. Hold on for the pandemic!

Hope it's a good day for everyone!
Take care,
Kelly

When I saw the topic of hep c and baby boomers in the yahoo health, and this was before the today show and NBC's coverage, I thought I'm glad I'm on the path of getting tx. There will be a huge influx of people looking for help. Either they will suddenly have a lot more trials or they will be filled up faster than ever.
I look at all my friends from high school, people I grew up with (on facebook) and think about who may have it and, like me, didn't know. How many had blood transfusions? How many snorted that one line of coke? Poof, you have it. Not a nice subject to bring up? It was the 70's and the wild and crazy 80's. Let's be real. If you went to any clubs back in the day, it was there to try.
Someone told me a few years back that whatever your vice was in your youth comes back to haunt you. (He was dealing with throat cancer from smoking.) It brings the visual (to me) of a club in Catalina Island where we all stood up and sang "the national anthem of California" Eric Clapton's Cocaine and the mirrored counter tops in the bathroom littlered with white powder. I'm worried.

Hey Lady, I went to see Dr. Galati this morning (actually I just saw Lauren), and they are recommending me for this trial! She said even for cirrhotics, it's only 12 weeks! Are you still planning to do the study here? I remember reading somewhere that you said you might go elsewhere. Or did I dream that? lol

Hey Sandy! Yes, I am coming to Houston. I'll be on the trial. I'm very excited about this. I know, I won't feel that way forever! Haven't you had tx from Dr. Gallati? Why is he suggesting this trial for you? That makes me feel like I truly made the right decision. He must think highly of the study to recommend it to you.
Hope to see you in Houston.

Lady I haven't had tx before, so that's why I'm still a candidate. Lauren at first told me they had no non-interferon trials available, but when she talked to the research person, Charlene, she told her that this one is available. She came back in all excited and smiley, which made me smile. :-) Even if the sides are bad, I think I can do 3 months! Let me know when you get here so we can meet for coffee or something.