I started taking MTX this past Tuesday again after being off of it the past 1-1/2 years due to us considering having another baby. However, I have never been the same since in regards to my RA and have had to get back on it. I'm taking 8 tablets a week now. My doctor didn't give my body a 'breaking in' period and so I was sick for two days with the first day throwing up several times throughout the day.
The only side effects I can recall and expect is a rash on both cheeks of my face, sores in my mouth and my stomach cramps at times.

I've been on MTX for nearly 5 years and really haven't had much problems with it. I take 25mg orally each week.

I've been taking MTX for almost four years. I take 25mg (ie 10 tablets in USA) orally each week. Next day, I take 10mg Folic Acid

I have had very little problem, except mouth sores at times.
Good luck this time around.

I took it for close to three months and the only bad side effect was the next day I was totally wiped out. My doctor just pulled me off it because what I was taking with it in between was making me sick. He put me on a new med but I'm having reservations about it and thinking of fighting this with Aleve. I can't handle all these meds with known and unknown side effects. Personally, I think they are doing more harm than good, at least in my case.

My buddy I used to get fishing with all the time told me the other day, he's had RA for years and at first he did all these meds. He was constantly sick and more less said the 'heck' with it and for the last four or five years, he's done nothing but Aleve and he seems to be doing fine. He said, he has pain and swelling at times but he handles that much better than taking all these drugs. I'm at that stage right now. I've been off meds now for a week and I have more energy, don't sleep all day or part of it. I was out shopping with my wife two days in a row and didn't get so tired I couldn't function.... Right or wrong, i'm giving it a shot. I'll keep you posted on my progress as the weeks and months tick by.

Today is my day , usually it's Sundays but I skipped yesterday to enjoy my hubbies early b-day surprise party :)
yes it maske me sick ..for three or four days after then have to take it all over again , more or less...
Im startting really bad pains in my stomach and the sores in my mouth too ....so today after breakfast .Metho day :(:(:( sorry RAfighter for all of this crap we have to go through ...
ive tried the lucovoran stuff , it does nothing to help ..and folic acid i take veryday like most of us ...

approx. 10 mos now, makes my tummy hurt and makes me super tired first day and gives me headaches, I cannot complain though, my pain level is almost nil now...like I am just a little achey all the time :D

oh and I take 6 per week

i just started the MTX. This past Thursday was my second dose, 4 pills (10mg). I'm doing fine with it so far. This Thursday I increase the dose to 6 pills (15mg). I'll see how that goes. Still, I feel fine.

As for side effects, I asked a friend who researched this drug for his dissertation 35 years about side effects. He looked up recent research and said: "You can expect a slow accumulation to reach an equilibrium after a few weeks. Then after 4-6 weeks you should know whether you will have side effects." He added that side effects can pop up later, but most show themselves early on.

I take six pills every Friday night. Have been on it since September. I get a little queasy, nothing some ginger ale can't help. The following day I am usually a bit tired, and for some reason I tend to get the chills. I also usually have a headache when I wake up on Saturday morning. Queasy and a headache on Saturday morning, when I didn't have any fun on Friday night...bummer! Other than that it really isn't too bad. I hope it does kick in soon, as I haven't really felt any relief yet.

I take 20 mg weekly and also folic acid daily. I've been on it for five months now and the eventual improvement has been remarkable, but very slow to see results intially. I've been lucky to have few side effects other than some hair loss and initial day-after feeling awful, but both of those have diminished greatly. I sometimes get a canker, but have learned what not to eat to keep those at bay. My monthly bloodwork has been good. Looks like it's a success story for me, at least for now....knocking on wood as I write this.

i take 15mg a week on sundays, last night was my sixth dose. the side effects were pretty obvious the first few weeks - it severely increased my fatigue mon-wednesday and i would have some nausea every day. ginger candy really helped alleviate the nausea. i also seemed to lose my appetite.

almost six weeks on, i am having fewer side effects. the nausea is very rare now and my appetite has returned. however, i get hungry and know i should eat, but i don't always want to and i never know what i want. you know how you'll feel hungry and be like, wow i could go for a burger or an apple or cheese or something? that doesn't really happen to me any more. the fatigue has evened out too. i still experience fatigue, but it's like 'normal' fatigue every day, it's not worse right after my mtx dose. however, i seem to have developed another potential side effect - sorry men, you might want to skip to the next paragraph. i seem to have been developing a yeast infection for about a week now. not too bad but a bit annoying. i'm in no way prone to them (unless on heavy antibiotics) and dr. google mentioned that some women do experience this side effect.

i also take rx folic acid daily, 1mg. my gp just added rx vitamin d as well. i am taking a multivitamin, calcium +d, folic acid, omega flaxseed oil capsules daily. dh and i just had a vitamin shoppe run yesterday and i'm adding in daily biotin and a probiotic.

I've been on MTX for close to 3 years (6 pills/week). I take half the pills on Saturday night with a substantial dinner, and the other half on Sunday morning at breakfast. The rheumy's office gave me a handout which suggested this method as a way to reduce the stomach issues some experience, so I tried it. I have never experienced any stomach issues, but of course everyone reacts differently. I've had lots of fatigue at times, but that is much better recently. When I have extended fatigue I remind myself that it's better than pain. I hope things improve for you soon!

Warelilly that is a really good idea ..when they say half in teh mroning and half at night ..then that means if our doses are close togethr like you do ..half at night then early teh next morning , that works ?? great idea ..im trying it next week ..thank you .

p.s. is rashes on teh chest apart of Metho????startting that too ..oh crapppppppp !!!!! :(:(:(

I self-inject .4ml weekly. Do NOT get sick at all. used to get sick on oral dose. Bene on it for more than a decade and at this point in time I am concerned about the CUMULATIVE effects.

Just took my 6 for the week, I have been on this amount since Feb, followed by folic acid daily and tomorrow Leucovorin for hair loss. Tomorrow I will be tired, more so than usual, but I haven't really experienced any horrible nausea(maybe the first month). I too worry about the cumulative effect, but then I think about where I might be without it. Hope everyone has a great day. Trish