I have been on MTX for about 4 months. Currently taking 15 mg 1x a week with 200mg of plaquenil. First few weeks were rough. Nausea and fatigue were intense. I had great results; lower pain and more mobility. Side effects are improving over time but pain and inflammation are returning. Possibly need higher dose.

Best wishes to all. Happy Thanksgiving

I'm really glad to see this on the forum. My rheumy is wanting to add mtx to the plaquenil. I'm very nervous about it. I want nervous about the plaquenil. I think when he said it was chemotherapy is when i freaked out.... it just made it all sounds so serious and scary. Plaquenil not being called chemo, i want afraid of it. He is wanting me to start on a very very low dose. I'm still scared of it.

I'm currently taking 8 pills a week. I'm supposed to bump up to ten, but I was heavily involved in a community theater project and I was afraid of dealing with any more side effects.

I took 4 pills the first week and jumped up to 8 thereafter. I had nausea off and on. 36 hours after taking the meds, I have a pain spike, so I have some tramadol that I take if it bothers me too much on that day. The first few weeks I have overwhelming fatigue at 36-48 hours. I got up late, slept the whole day, and then went to bed early.

Now isn't so bad. Then again, I've always had the stomach of a goat, so I just hope that holds out. I do take folic acid every day and I take a probiotic that helps a lot with my digestive system.

Poopies!!!!! I think I jinxed myself when I posted how well I was doing on MTX. My Rheumy's office just called and said my liver enzymes were up a bit on my last bloodwork so he's cutting me back from 8 to 6 week. I sure hope I can continue on MTX and that it keeps working for me....I'm pretty bummed out right now.

Ahhh Volks..... I'm so sorry. I wish u the best with getting your bloodwork back in order.... and staying pain free.

I took my first small round on Monday night.

No effects really the next day. I was able to put in a full day. And today it seemed like it took less time to get going in the am even though i walked a mile and rode the bike for 25 minutes yesterday.

Today i have so much energy i am almost euphoric. But i better slow down so i won't poop out tomorrow.

So far.... it's been wonderful. And i know this thread helped me with my fears. I finally decided that if it works for other ppl or can work for me, too.

Xo

O, i am starting out very slow with this med bc i have CFS and do not want that to kick it into gear....