CeeJay, I never heard of warfarin directly causing pain. But pain there was; I enquire, and was told it was part of healing, Bits here and here that had sit down and were now rebuilding since they were at last getting oxygenated properly. Just like inhaling CO, which displaces O2, will shut you down and eventually kill you. YMMV,

Bilateral massive PE - two clots that broke into 4 - plus a few right leg DVT. Had a few test since, including arterial ultrasound, all is clear. As a bonus I learned I do not even have diabetic arteries; but it is suspected I may have valve damage and blood pooling in lower limbs.

That may be the cause of the DVT, and in turn of the PE. nothing for sure. Nothing genetic could find, nothing blood work could find.

We here are the lucky few. 25% of sudden deaths are caused by PE, with no prior symptoms except a bit of shortness of breath. In many cases the answer is the politically corrected "stuff happens".

I was at risk as a 10 years brittle diabetic with Hashimoto thyroiditis. Both a related to an overactive immune system; I was rarely sick until the sky fell out.

Thanks for the response... my INR as of this morning is 1.9. I was increased from 6.5 to 8 mg of warafin on Saturday, which raised it to 1.9. I took my last shot prior to going to get my INR tested.

I sometimes have pain in foot and arms and legs.. nothing long lasting.

I see my hemotologist today and will mention to him.

If you're really anxious, sometimes that can cause your body to start responding in really weird ways.

Plus having such a big life threatening event may make your body respond that way too.

My INR goes up for a couple days to 2.2-2.3 and then when I change to 5mg warfarin it drops down to 1.9-1.8 and then I have to increase to 7.5mg again. It's been two weeks for me. How often do most people go for bloodwork to start with and how do you manage the incessant ups and downs?

initially i was every 3 days for blood tests, then weekly, then fortnightly but since the start of january ive been back weekly as its never level - just keeps dropping and i feel really rubbish right now. had more tests this morning - im hoping its above 2 again - but i suspect it wont be - i just wish i could get to the right level and get on with my life rather than this constant circle of blood tests, increase warfarin, feel yukky, feel good, blood tests, and so on. is anyone else in this same circle as me?

I'm not now, but was when I first started warfarin. It took about 6 months for me to even get my INR to at least 2, and quite a while for it to stabilize after that. Try not to get too tense about it. It is aggravating to keep testing, I know. But I really believe getting stressed about it doesn't do you any favors in your overall health and recovery.