There are a lot of reasons for your night symptoms some of which could be related to MG. Mestinon increases your secretions of mucus and saliva. These may be more noticeable at night (especially if you take a mestinon right before going to bed). Position when sleeping can put more stress on muscles related to breathing. Insomnia has many causes also. Secretions and breathing may be waking you up throughout the night. I’ve had all these plus night sweats first caused by cellcept and later made worse by menopause. I have not slept well in years. Meds have the potential to disturb sleep. I barely sleep at all when a flare forces me to add prednisone to the mix of meds. Not sure if that’s a common thing among group members. Have you had a sleep study? One may settle if MG is causing your issues or if it’s something else. Meds may also interfere with sleep study results too. All that being said, you need to discuss this with doc.

sorry to hear you have MG, but it is treatable and most of us get a treatment figured out that lets us function decently.

Mestinon did cause a lot of secretions for me. From sweating, to drooling and bathroom trips.

Cellcept is slow to take effect, some folks say months to a year or more. I started with prednisone and mestinon to get quicker improvement as I was quite limited in functioning
until the prednisone kicked in -- a few months.

At the same time I was diagnosed with MG, I was diagnosed with sleep apnea and so got a CPAP machine for that. It made my night breathing greatly better and when I had breathing problems during the day (often in the first few months), I could use the CPAP and it made my breathing work OK. A BiPAP is generally better for breathing difficulties of the MG type, but my CPAP was one that pushed air in and relaxed some to let me breath out.

I don't think my sleep apnea was caused by MG, but it did appear at about the same time.

Good Luck
Russ

well
If you aren't taking mestinon before bed that could be a factor. Making sure you get mestinon before bed may help. There were times in this journey that I took mestinon when I got up in the night time.
You are tired before bed so symtoms will be worse. After sleep you symptoms will be less because rest helps us.
When I am on prednisone I don't sleep well, At 20 or below I do ok as far as sleeping is concerned.

I too have a big problem with sleep. Wake up 2-3 times every night to run to bathroom. I have UC, so the meds that stimulate the digestive tract really do a number on me. My GI and Neuro have tried multiple meds to help, but none seem to work well. I don't take Imodium( an anti-cholinergic) because I take Mestinon(a cholinergic), They tend to compete with each other. I'm now taking Colestipol, which has the side effect of constipation. Helps a little, but not much. I sympathize with you. What I wouldn't give for a good nights sleep. Cellcept 2x500mg 2xdaily, mestinon 60mg 5x daily, prednisone 5mg od. Be well, peace, joker46

Thanks to all for your comments. My sleep issues are not being able to fall asleep at all until 4 or 5AM even with not sleeping during the day. Seems to be medication related because I never had the problem until recently, but I don’t know. I am recently retired which may be a factor. Also, I seem to have the inability to clear phlegm and secretions only later in the evening and at night regardless of whether I take 60mg, 90, or no mestinon before bedtime. This condition began just prior to my double vision symptoms. I am trying to understand if the choking sensation and inability to clear my throat is something others experience or if perhaps I have something else going on.

You should see an ENT they can do a laryngoscopy. They can look to see if you are having pooled secretions in your throat and if everything is working normally including vocal cords. I’ve done this twice. They say my issue might be reflux., it can give you choking sensation and spurts of secretions. Especially since you say it’s after dinner. . I am antibody positive MG. I get symptoms mostly in my face and throat that are very mild but annoying. My symptoms come on about 4 pm every day So I understand what you are saying.. I don’t know whether mine is reflux or MG but they are gone by morning. I don’t have the secretions just the choking sensation. I have a dry sensation just the opposite.
I don’t treat my MG it’s been this way for years. I figure side effects are worse than my symptoms. If I get worse I will. But I do tend to blame most things on mg even if it might not be. This is a confusing condition to have.

Can anyone who experiences breathing issues explain how and when symptoms present themselves. I continue to have insomnia issues and am finding that when sleep deprived I have shortness of breath and need extra breaths and have to concentrate on my breathing.

I find if I have issues with breathing at bedtime, I elevate my bed. I am lucky to have a sleep number bed ( great investment I made before I got sick) But you can use extra pillows.

I have issues with feet and leg cramps! Always something. I will be starting Soloris within the next few weeks.