Hi Dee. I have been taking Mestinon for 2 weeks and I have noticed the same thing, also I need to eat throughout the day. I try to snack, not big meals and trying to eat something healthy, no McDonald's, (not that I ate that anyway). This started the first of the year for me and it has been so frustrating, as my blood work came back negative, but had abnormal EMGs and of course the symptoms could not be denied. I was very active and now I am happy if I can just get out and walk my dogs.

The thing that bugs me is there is nothing I can do to help resolve this, other than hoping for remission. I was so active and in good shape for my age (69). No weight problems, no smoking, and this came on like a thief in the night.

I appreciate your reply. I do find this site very helpful.

Once the prednisone was effective I switched to mestinon as needed. My near says it is like aspirin. Take it when you have symptoms and it will help with the symptoms, but not the underlying cause. I am down to 50 mg every other day with my prednisone now (started at 60 mg every day). So far no deterioration or symptoms, hopefully the cellcept is starting to take hold and I can get off the prednisone. I actually feel better on the days I don't take it, which I am hoping is a good sign.

Thanks Guy that was helpful. So if you take prednisone you don't take the Mestinon with it? Neuro has not mentioned Cellcept, at least not yet. I guess I will find more out this week when I go. At least I am getting some relief with the Mestinon as for 3 months I didn't take anything because the neuro didn't want to prescribe the wrong medicine as he was unsure about my diagnosis. I still think he is still unsure, probably just figured from the symptoms it was MG and I need to start the Mestinon.

In my case, the prednisone took care of the symptoms so I am not as reliant on the mestinon. The plan is to get me off prednisone since it is playing havoc with my sugar levels, and get me on cellcept. The cellcept can take up to a year to take effect (assuming it does), so hopefully once the prednisone is tapered down to (hopefully) zero the cellcept will take over.

Prednisone is a deal with the devil in my opinion. It can definitely help MG in most cases, but the side effects are severe in some cases. In my case, I had breathing problems early on so it was necessary. If I can get off it, and be relatively symptom free I will be happy. Last December when I was having major difficulties I would of given anything to feel as good as I do today; even though I am not as well off as before the symptoms appeared.

I need mestinon and prednisone for years along with phersis until 1 yr ago.everyone requires a different mix.you'll figure it with Dr what your cocktail is!

Mestinon Timespans are not recommended for daytime use in MG. dissolution and absorption is inconsistent and irregular resulting in variable effects. In addition, it is substantially more expensive than generic immediate-release tablets.