Hi Azmo.....my first two doses were miserable and then after that my body seem to adjust.

I started injections last 2 weeks and was HORRIBLE. I tried ginger tea and YUCK....so I did what you do for morning sickness....ate saltines and had black tea and no nausea.

I learned coffee was horrible for me and my RA. That caused horrible nausea due to the acidity so switched to tea.

Your body will adjust, takes time. Hang in there. hugs

The first time i took methotrexate i felt like crap for 3 days. Tired,headache, just icky i slept the weekend away. I didnt like that so i read where others had split the dose into two times the same day. I would take 3 tablets in the morning and the other 3 after supper. That took some of the tiredness away and eased the headache some. I did go off of it because i didnt function well on that medication. Good luck to you

I am taking MTX injections, much easier to handle then the pills. I couldn't stand the way it made everything taste metallic!

I remember the metallic taste when I started on Methotrexate. Took all of the fun out of eating and even water didn't taste right. But it went away after a month or two and never returned. Never had any nausea after switching to injectable MTX. Those were the only symptoms I have had with the drug in a year of taking it.

Splitting the doses in the day makes for sound advice. Much appreciated. I am very active and must admit it kicked me. I'm from AZ but now in MO (hence the name) so I drink a lot of water. Putting the ginger in the water helped a lot and just managed to sleep off the headache and watched more movies in 2 days then I care to admit. I really didn't have a metallic taste in my mouth but then again I'm not sure I ate properly. Eating for a necessity vs. nutrition isn't a good way to live.

Glad I found this site because I knew I wasn't alone in this new curve in my life. Truly appreciate all the kind words.

I was on pills at first, and it took 6 week to get rid of the nausea. But the pills never worked well injections in combo with a biologic was the magic bullet that put me in remission for 5 wonderful years.

I would love to go back on mthx, but the liver doesn't like it, for unknown reasons.

Don't give up in the mthx, these drugs take a while to work.

I have been taking the injections .06 mil, and folic acid for 3 weeks now, along with 20 mil pred. Small short headaches and little nausea, not too major. Have a miserable cold which turned into upper resp. infection so have to take antibiotic so no methotrexate for me this week. I will start tapering the prednisone tomorrow which I'm really excited to do and dare to hope to continue. Told the doc today that if I didn't feel so bad I'd feel pretty damn good! At this moment, I can cross my fingers hoping you will feel better soon.

I was diagnosed late in 2014, started on plaquenil in early 2015; added methotrexate in early summer last year, 6 pills/week; increased to 8 pills/week in November; now Dr wants me to try injections - maybe won't cause the nausea (and diarrhea - on a couple other meds that can cause that side effect too, so hard to know which is the main culprit!). Will take first injection this upcoming weekend, so will have to see how that goes. Any other advise would be appreciated - sounds like the injections didn't cause as much side effects from the comments I've read. I hope you have success with it AZMO. This group has been a great resource to me on my RD journey so far! HUGS!