Hi Keren: I'm still pretty lost on the Ig stuff, too. But, because my Igs are so low and the Ratio is dropping, docs want to make sure that I'm not "smouldering" something. It can't be myeloma, because I don't make the cells. But, it could be a smouldering lymphoma/leukemia according to a long-ago haematologist.

So, the very rudimentary connection I see (and I haven't yet looked at your links, sorry!) is that if IIH is in part an outflow obstruction -- be it via lymphatic system or impaired arachnoid granulations, etc -- and if my lymph nodes are enlarged (according to my general doc/internist) and are not moving fluid unless they're manipulated, then I keep thinking that there's gotta be a connection. And, because of all the immunology & haematology responses of "whoa, that's too odd to be coincidence", it makes me wonder. BUT, I've not done a lot about it because of other fires to put out.

As for over-production, having been shunted 3 times & had them over-drain even at the highest setting, and having ended up with slit ventricles, I don't buy over-production or hydrocephalus in my case. It has to be an outflow obstruction and mine isn't venous because the angiogram "said so".

In truth, I have no real theories, just a "wondering". But, I'm at a stage where the docs aren't listening to me even about the basics, so haven't really come back around to any of this. It's on my short list for my trip to specialty headache center/IIH specialists.

well the first paper deals with CSF drainage via the lymphatic system - there haven't been human studies, but "The lymphatic pathway has been shown to provide drainage for 4050% of CSF in rodents and sheep."

The second paper deals more directly with IIH but looks more at jugular venous out flow - still an exit method but not lymphatic. Still it is a good case study that lends credence to the argument that out flow is the issue rather then production. and combine that with the 50% from the lymphatic drainage and.......

sorry pressure forgot to say - i know you said your headaches had been wiping you out and you hadnt been up to much recently - hope you manage to catch a break soon!!! big hugs xx

Thanks, Keren! So, outflow resistance. I read your 1st link (or should say stumbled thru words I knew) and now it makes sense why every head MR mentions the "probable granulations" at the sagittal top. LOL.

When I was readying self for angiogram, I found an old article about venous outflow obstructions and elevated ICP. There was a young man on this board a while ago whose father was investigating elevated venous pressures. Anyway, I downloaded the article into pdf on my hard drive and have no idea how to share it (how do I upload?). But, there was an OLD, but interesting illustration from the Barrow Neuro Institute that accompanied article. It's here: http://www.neurology.org/content/46/1/198/F1.large.jpg

Basically, article drones on and on about stenosis and/or thrombosis, weight, etc, but diagram shows left side high ICP WITH venous outflow resistance and right side high ICP WITHOUT. Normal venous pressures are 0-4 mmHg.

If lymphatics and/or granulations are all compromised thereby creating an outflow resistance, it would increase venous pressures, yes?

My venous pressures are elevated, but the outflow on angiogram was described as "rapid".

I can't get into to your 2nd link BTW. Sorry, challenged here. :) Thanks for nice wishes.

hopefully you should be able to see the second link now - its on google. thats how i share pdf's. (i had forgot to change the setting on that file to public) but I upload them into my google drive just like i did with the symptom spreadsheet. If you are on google you can do the same with your pdf's or you can email them to me and i will up load them for you :)

Thats interesting about variable venous resistance! i would be interested in the paper. I think you will find this second link very interesting too.

neuro went as expected she passed us on to an NO in Grand Rapids for a shunt and I just don't think its enough time. I have no visual changes and pressure in my eyes are normal.....but I do have intermittent hearing loss, guess I will have to see how it goes

I hope everyone is doing well today :D blessings Aim

Waaaaait a minute.

On depressed Ig levels (primary immunodeficiency). On the dailymed.gov site I read that Diamox can cause leukopenia. But I don't know if that's the same thing. I'm not sure it is. Any doctors on here, I know it's been a long time since you've read up on immunology, but if you remember any of it this'd be a great time to chime in.

Bless you, Sea! You are a reference dream. So I think leukopenia is low WBC especially including Neutrophils and IS an immunodepressant condition. I think also it can be predictive of leukemia and other bone cancers, but not necessarily exclusive to. I have low IgA, IgM, IgG & IgD (D still within range, tho). But, I have in-range WBC, Neutrophils, lymphocytes, eosinophils & basophils

I realize my earlier post cut off my Ig #s. IgA=446; IgM=10; IgA=

Pressure :)
outflow resistance.
that old article you mentioned before about venous outflow obstructions and elevated ICP. here is the article you sent me in pdf.

https://drive.google.com/file/d/0B1tnUf7D0KttZEhOdk02a0c3X00/edit?usp=sharing