Polycystic Kidney Disease (PKD) Support Group
Polycystic kidney disease (PKD) is a progressive, genetic disorder of the kidneys. It occurs in humans and other organisms. PKD is characterised by the presence of multiple cysts (polycystic) in both kidneys. The disease can also damage the liver, pancreas and rarely the heart and brain.
A team of researchers at the University of California, Santa Barbara, directed by Thomas Weimbs, Ph.D, a professor in molecular, cellular and developmental biology (MCBD) and in the Neuroscience Research Institute at UCSB, has recently discovered that reducing food intake in mice can substantially dampen the rapid proliferation of cyst growth in the kidneys and in turn preserve kidney function.
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The findings have also shown that mice administered with a 23% reduction in diet, exhibited a 41% reduction in kidney weight growth over the course of a 7-week period. Meanwhile, the mice that were administered the normal non-reduced diet exhibited an increase of 151% kidney weight growth also in the same 7-week time period. The researchers also discovered that the cyst-lining cells in the reduced diet mice proliferated 7.7% while the non-reduced diet mice had their cyst-lining cells proliferate at 15.9%. Further examination of the mTOR pathway also revealed that the mice that had been administered the reduced diet had two of their activating signaling branches of mTOR suppressed. This would make reduction in diet more effective than pharmaceutical rapalogues, such as rapamycin, which only suppresses one activating signaling branch.
http://dailynexus.com/2016-02-25/the-kidney-saving-diet/
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The findings have also shown that mice administered with a 23% reduction in diet, exhibited a 41% reduction in kidney weight growth over the course of a 7-week period. Meanwhile, the mice that were administered the normal non-reduced diet exhibited an increase of 151% kidney weight growth also in the same 7-week time period. The researchers also discovered that the cyst-lining cells in the reduced diet mice proliferated 7.7% while the non-reduced diet mice had their cyst-lining cells proliferate at 15.9%. Further examination of the mTOR pathway also revealed that the mice that had been administered the reduced diet had two of their activating signaling branches of mTOR suppressed. This would make reduction in diet more effective than pharmaceutical rapalogues, such as rapamycin, which only suppresses one activating signaling branch.
http://dailynexus.com/2016-02-25/the-kidney-saving-diet/
Thank you for sharing this information. I ll make further research on how much is mTOR signaling pathway involved in PKD progression. It seems simple and completely safe way to slow cyst growth and probably some other diseases in which mTOR is involved (carcinomas maybe).
Best wishes,
Shedoctor