Your dosage of Mestinon is tiny, if only 25mg per day, as indeed would be 30mg every 4 hours. Mestinon only 'works' for around 4 hours at a time. Not for me, or indeed anyone else on here to suggest you need more and most of us that take it have gotten used to ourselves and our symptoms to the point that we vary our intake, according to how we feel. As has been said many times on here you need to make contact with your Neurologist and get some advice. Hopefully, you are able to do that? If it helps I do not take the same amount each time, but it has never been more than 60mg (one tablet) at any one time since the early diagnostic days over ten years ago. If I am going to talk/give a speech I will take 60mg an hour before other than that it's usually 30mg, two or three times a day. I do find that taking too much will adversely affect me but my Neuro doesn't believe me! He thinks the dosage needs to be in the hundreds 250mg plus- but what does he know, he hasn't got MG!

sorry to hear you are having problems. Mestinon does help most of us, but there are cases where it doesn't help. It tries to make better use of what receptors we have that are not blocked or destroyed. If we are too far into the destruction, there aren't many receptors to help and so that is one serious possibility. There are different types of MG and some, like MuSK don't always respond to mestinon (about 1/3 don't with MuSK). LEMS type MG also has less and sometimes no help from Mestinon.

If I were testing mestinon, I would try one dose of 60 mg to see if that helped. If not, then try one dose of 90 and if not one of 120. Since mestinon only takes half hour to work and wears off in about 4 hours, you can try this on your own. My experience was that 60 mg every 3-4 hours was needed to help when I was at my worst. When I tried 90 it made me a little too twitchy, and 120 made me more so. My doctor said I could take 120 at a time if it helped, but should limit myself to about 8-60mg tablets per day.

Good Luck
Russ

Thanks Russ and Peter,

I did just try a dose of 60 mg and did not see any benefit, or any worsening!, although possibly a slight improvement in my eyelid droop. Maybe I will try a dose at 90... I am looking for something that will help my legs, they are always so weak and tired now. (I Have a plasma exchange in 2 weeks, can't come soon enough)

Thanks again!
Joel

hi joel, the plasma will help you to function properly as long they give you a staged treatment meaning a sequel of doses.,if you can look i give an explanation of th importance of mestidone and prednisone, i just want to add a important factor regarding mg. for you all mg was discovered in 1672 almost 400 years ago by thomas willis, and is no the first, now isnt it the fact that in all those years not much as been done by doctor and ect...??? amazing all way to live with mg. as been left to every patient, we all ahve been practicioners, patients, guinea pigs. and even today they playing dum.
also i want you to think about this, get yourself a hand tenssil machine use it every day for 10minutes. that will help, your spams. cramps, leg pain , i use it and fell much better, luck to all Andre(fighter)