Should be easier to manage with regular mestinon tablets.The release of mestinon into system is not consistent when using mestinon timespan. That seems to be the biggest knock on it. When I really needed to take mestinon, I would take my mestinon timespan and just take a little extra from the normal, mestinon 60mg tablets when I was to be very active. Eventually, I needed to only take as little as 30mg when I was to be very active. Get rid of the timespan if you can. Some people like it, but results always seem to vary.

Anyway, keep in mind that your shouldn't expect optimal result from either type of mestinon for at least 1.5 hr later after consumption. Do things when you are at your strongest and save your spoons. Need rest.

I had awful twitching from reg mestinon so started tr mestinon. I also add 30 or 60 mg reg mestinon when I need it also.I my Dr is great about having set limits but allowing me to juggle meds. I do keep log of results,symptoms, etc. Good luck

I can not take time span because my metabolism is very slow. Make sure you do not cup the time span in half since it is time released, and it could mess up the dosage released. Best Wishes.

My experience: 60mg mestinon 4X daily (5am-9am-1pm-5pm) then 9pm I take 180mg TR to get me through the night. Has been very effective for me last 15+ years.I lead a very active life style - crossfit-running-hiking. I was diagnosed in 1991 and mestinon was effective from the start.

Did you ever take prednisone? What is TR?

Tr or ts is short for timerelease. Some brands of trmestinon can be split some cannot. It has to have a score line and ask pharmacist

It seems the TR is rather questionable, so I may just stick with what I have. I just set the alarm on my phone for when I need to take it. Easy peasy!

GrecoGirl - I'm new to this -- first started having symptoms regularly in mid Feb of this year. But I asked my neuro the same question, and she said the time release version isn't as effective as the regular dosing.

Sounds like you plan to stick with regular Mestinon, but I will add that Mestinon time release is MUCH more expensive. Your pricing may vary based on insurance, but the regular Mestinon is available as a generic, so it will always be cheaper for the same amount of coverage. Can't remember what my cost was so I just looked it up on goodrx to see what best price is without insurance. For Mestinon 60mg, 90 tablets, best price is $32. For time release Mestinon 180mg, 30 tablets (to keep it same total dosage for comparison purposes), best price is $288.

I use my cell phone alarm for everything! !don't know how I remembered before it. Grandkids have to switch tablets etc when it goes off, meds,laundry,time to go somewhere. I forget occasionally when it beeps what it's for. I also write on top of my hand so I don't lose a little note in pocket, phone #s etc. I put keys in fridge if there is something I need to bring with me. The tricks and old lady has learned. My kids laugh but I tell them ,they will do the same thing. Have a g re at weekend

LOL, that's too funny. BTW, you can put your notes on your phone too. One thing I have to do is remember to take my phone off vibration. I don't hear anything and then when I get to it, I see all these missed calls, etc. Getting old is a bitch as they say. It certainly ain't for sissies and now this stupid thing with MG.

TR (Time release-180mg) is intended to get you through the night so you don't need to wake up every 4 hours to take a 60 mg pill. you take the 60 mg pills during the day, spaced every 4 hrs...then 180 mg at night. This is the only med I have needed since being diagnosed with MG in 1991.

This old lady still has the little black flip phone. It's the only 1 that fits in pants pockets. I always have with me JUST IN case. So I don't text but I can read any text sent to me. Hubby calls everyday at 1130 just to make sure I'm ok.gets annoyed if I don't answer asap.getting old is a bitch but at least we are there!!

TR through the night. I seem to sleep okay and eat okay. I finally switched from half tabs to the whole tab 3x daily. My last one is usually between 10 and midnight and I seem to do okay until morning. I go see my neuro this week and he will probably want to start prednisone, but have to wait and see on that.

I am take Mestinon 4x's a Day. However, if I miss one. My body usually will let me know. My feet start to shuffle, my husband will say "take your Mestinon" Your body will give you the clues.