I tried with Google translate, and think I got the idea--there may be a mutation in the mitochondria in hereditary fibromyalgia. But it is not so easy to read technical stuff in Google translate.

I don't really understand how they would treat any mitochondrial disease.

But it is interesting, and all research that isn't about our disturbed psyche it good in my book.

No history of fibro in my family.

Also, I am hoping my son doesnt get it from me.

WOW, great article!! I have always said I believed I inherited it from my birth mother (I am adopted). I found her a couple years ago one year after she passed away; however her daughter knew about me and has been sharing quite a bit of info with me. She was quite debilitated with both fatigue and pain beginning early adulthood like me and I am the spitting image of her (her first born too). Very interesting, especially the part about the mitochondrial dysfunction which I interpret as the fatigue.
Here is a direct translation of one section:

"In our research, we show a mutation in mitochondrial DNA in a family with a diagnosis of fibromyalgia with maternal inheritance. This mutation was responsible for mitochondrial dysfunction described in patients. In addition, the mutation present in the family was associated with the activation of the inflammasome NLRP3-who was also present in cells of other diseases with mitochondrial disease mutations as MELAS, MERRF or complex Leber's disease, "explains Professor Seville University and lead author of the study, Mario D. Lamb .

Both fibroblasts and cells in urine, blood, saliva, skin and platelets main study patient showed the mutation as well as mitochondrial dysfunction and inflammasome activation. Family members matrilineal (sons of the patient, the patient's mother and brothers of the patient) showed the same mutation as well as mitochondrial dysfunction and activation of the inflammasome. After, mitochondria transplant patient healthy cells without mitochondria, these equally ill activating the inflammasome. These results were also observed in fibroblasts of the other three mitochondrial diseases while inhibiting inflammasome improved significantly the growth of cells.

"Our study may represent a new therapeutic target to investigate mitochondrial diseases since inhibition in cells with mitochondrial mutations showed a significant improvement in the cells. The NLRP3-inflammasome complex represents a new field of research in mitochondrial diseases, "he adds Lamb

I wonder if by "inflammasome" they are taking about the inflammation theory like what was just represented in the latest study by the National Fibromyalgia Assn?? ANYBODY?? maybe this is an inflammatory disease / mitochondrial disease??

No history of Fibromyalgia in my family except my father.

There's a thousand theories, and for my money several "types" of FM that need to be sorted out, but.... Interesting stuff. Also, my hubby is Spanish-fluent so he translated the non-technical words for me, LOL.

No history here either. But, my Dad had many of the conditions that can be associated with Fibromyalgia. I often wonder if he was never diagnosed as it is not that common in men.

I always thought it came from my father. Two of my brothers also have chronic pain. Although, my Mom in her sixties had what she called "arthritis" and some sort of brain fog. Maybe it was the double whammy.

I DO hopr it was at least somewhat helpful. I came across it on my university website where I'm working at the moment (I have MS, not Fibromalgia, but I know several MSers with both, so I wanted to help!)

Anne8 - Thanks for sharing!

Thanks for sharing this! I'm going to look into it further. I'm 43 now, but was diagnosed with FM in my early 30's. It's progressed to the point where I'm now on disability. I've always speculated that there must be some kind of hereditary connection (at least in some form of FM as one of the posts points out). My mom was diagnosed also while in her 30's and my brother has FM, as well.