Well, this is starting to sound like a lot of miscarriages. although I don't know their prevalence in general to be able to judge if it is more than usual.

My mother did not have fibro. and neither did anyone else in my entire family.and no other miscarriages or infertility in my family as well.

I swear I was adopted. (I know I wasn't, I just am saying that because I'm the only one with fibro and pcos and infertility and cfs.. and all the other things I have since been diagnosed with..)

I also thought this was a venting post at first, lol. Then thought maybe a new medicine. I'm a little confused about the gene. Does it always cause low Vitamin B? I've always had normal blood work with the exception of low blood sugar at times, and anemia believed to be associated with too much blood loss. I also had a miscarriage, but no known cases of Fibro up the blood line. I heard a rumor that a cousin has it, and my sister claims to have it. She, however, has serous neuropathy issues with many other health issues from complications of Type 1 Diabetes.

Wondering if it would be worth getting tested for this gene defect if only to help in the research of Fibro. (No more babies allowed for me, but not due to infertility.)

The 1298C gene has to do with poor Methylation ...etc....

I wouldn't link the two as far as miscarriages go...

http://mthfr.webs.com/


I found this Blog -- its more specific to the 1298C mutation-- which correlates with Fibro etc... ( NOT a cure- we all know there isn't one)
People who have MTHFR mutations have an interruption in the Methylation Pathway." This is the focus here and basically whats important -- well done blog.

http://mthfr.webs.com/resources Do NOT miss this page... incredible resources!

Thank you. My fibro doctor is on that great-fibro-doctor list that gets posted regularly. I mentioned it to ger Thursday at the support group meeting and emailed her a bunch of links. Told her that I want to get tested. Let's see what she says.

I haven't heard about this. Not sure if it's my problem or not. I do have issues with B12, as does my mother. Hers was so severe for so long that she ended up with pernicious anemia. My B12 is low normal & my neurologist has had me supplementing to get my level up up 500-600 where she wants it. After 6 months it has only gone up to 320 from 240, though. I have the same difficulty increasing vitamin D.

I had 3-4 miscarriages, but always attributed that to PCOS and my hormone issues. But, now that I have been in menopause since 39 and researching that to see the relationship with thyroid...and thyroid can be related to heart issues... Who knows? Maybe this mutation does have a hand in all the interplay. The tangled webs are more intricate than doctors want our bodies to be. Rarely can one organ or system be treated in isolation.

Birth warrior, I don't understand it well, but if you will look at the material in the various links that have been posted in this thread, it seems that regular folic acid could be "bad" for people with this mutation/cannot use it. But b vitamins are very important and a methylated form (whatever that is) can be digested well.

BTW, Sublingual b12 is absorbed best. Antacids prevent absorption, but then no one takes antacids just for the heck of it, so if you are taking them, there's a good reason.