i have wondered that same thing! i think arthritis is associated with CVID...i know i have bad joint issues and i'm only 22! also last month i dislocated my shoulder and tore my labrum just by accidently knocking over a glass of water! i think we just are fragile creatures haha

There is definitely a higher incidence of autoimmune illnesses and CVID. Arthritis and irritable bowel syndrome are reasonably common examples of these.

Are you on IVIG or subq? I used to feel really crummy when I was on IVIG in my "trough" week....extremely achy (more than my normal day) and would even start getting sick during each of those weeks.

I'm on subq and the IgG replacement has not helped my arthritis. The last year or so even my muscles ache when I walk. A couple of weeks ago, I developed pain in my shoulder when I extended it, thought I slept wrong, but unfortunately, I can't lift it and it hurts SO bad I'm on a heating pad every night now :( Back to the doc I go!

Was on ivig , and went off because side effects were in tolerable for me ( everyone is different and variable0 So I switched to sub Q---slow rate to where I need it to be whih helps with site reactions a lot. I give myself in small increments with a five 10 minute break before infuing the rest , then do not get qs much burning and itching.
Have been on sub Q about 1 month. My bones, joints, shoulders , neck, and even ribs hurt. Chest tightness, and a dry cough. My elbow have been so bad I have to take one arm to lift the other. Report says no RA Body says---somethings sure going on :)

I could hardly lift my legs yesterday---just tightness and pain everywhere. This dry cough is getting annoying---one day it is there , then the next gone---only to return a few days later agin. Why is everything so flippin unpredictable, undiagnosable, variable.........lol !!!!!

have them ck potassium, calicum, vit d levels...mine bottom out from time to time now my rhuemo includes them with my reg blood work....also i did develop autoimmune issues that are being treated BUT it was a long rd because the treatment is counteractive to the immune def treatments.....it is a tightrope we walk with all my docs working very closely together....have them ck your sed rates that is where they started seeing additional problems where brewing...mine were over 100 it should be 0-20...from there my rhuemo started running lots of tests and my hemo, internist, and rhuemo had a 3 hr pow wow to discuss treatment options and came up with what i am now doing...it has helped i am seeing improvement....
BUT i went through a LOT of rheumo docs before finding one that could handle cvid and auto immune issues...she trained under my hemo doc and immune doc and my immune doc is a rheumo/immune doc so she knows her stuff...the ones i had been to over the yrs had no clue what to do with me...you may have to go through a ton...
also y auto immune symptoms had become so bad quality of life was none so the option to treat me with immune suppressing drugs wasnt done lightly also i am now on a very high dose of ivig 60 g every 3 wks to counter act.....but i am doing much better....even with the latest flare from the stress of loosing my son...my doc got it under control in a day or 2 by changing med doses...
so there is help if it gets out of control and they can dx d treat auto immune even with immune def.....dont give up look for a doc that knows their stuff and can help...i went through my internist and he sent me to who would work with him and someone he trusted...

I have been experiencing the same. I started subQ in January (no IV IgG first). My doctor said it will take 12-18 months for all of the inflammation to settle down. He increased my weekly dosage of IgG by 1/3, and now, 3 weeks into the higher dose, I made it through my first week where I wasn't in agony with muscle and joint pain and taking painkillers non stop. He did however say that it might be RA, and that we would have to monitor it.

You might want to see if you need a higher dose as another possibility. It seems to be working for me although it worked gradually.

I've been struggling with this too. Mine is mostly in my hands and feet because of neuropathy, but I've been struggling with the whole body pain for some time too. :( Mine gets worse for about 48 hours after subq treatment