Common Variable Immunodeficiency Support Group

Common variable immunodeficiency (CVID) is a group of 20-30 primary immunodeficiencies (PIDs) which have a common set of symptoms but with different underlying causes. CVID's underlying causes are different, but the result of these are that the body doesn't produce sufficient antibodies in response to exposure to pathogens.

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2nd Month Doing IVIG Question

thesauce
thesauce

Hi everyone! I just did my second infusion of Gamunex-C.  The first month they did the infusion slowly.  I had 3 days of feeling like I had the flu after the infusion.  It was only severe on the first day.  This month they did the infusion fast, and I am on day 4 of severe flu-like symptoms (fever, nausea, mild rash, shakey/weak).  Also, I am getting migraines every day.  Is this normal????  I feel fine during the infusion.  The side effects always kick in the next day.  My daughter thinks it is worse this time because they did the infusion at a faster rate this time.  Should I call my doctor or see how it goes with the next infusion?  I still like Gamunex-C once a month vs. Hyzentra every 7 days. I did Hyzentra Sub-q for a year and never felt good.


Susan

sonnycamehome
sonnycamehome
It sounds like you are having a more severe reaction because the rate of infusion was to fast. You may want to speak to your Dr and ask him/her to write orders for a slower rate of infusion. It can take several infusions before your body can tolerate a faster rate, and even then the rate should be titrated up slowly.

I'm sure you know this, but just a reminder to hydrate before, during, and after your infusion. You may also benefit from continuing to take Tylenol and Benadryl until your side effects go away.

Hoping you feel better soon :)
thesauce
thesauce
Hi! Thank you for replying. I didn't think a fast rate would affect me after the infusion. You seem to be in agreement with my daughter. I will insist on a slower rate next time.
stefann
stefann
Hello there. Definitely seems like the rate of the infusion is an indicator. During my first infusion I had the worst migraine headache for days. After that first infusion I let my nurse know and they slowed it down which helped. Your body my also just need to adjust to the new type of plasm you are receiving. I do agree with thesauce that pre-meds (Tyenol, benadryl) before and after the infusion do help and hydrate, hydrate, hydrate.