Meds not working at all

Well, yesterday I never got out of bed due to my overwhelming depression.  Even though I take my med faithfully, they just aren't working.  I don't know where to turn.  I see a psychiatrist and and therapist and nothing is working.  And it's not just Gene's death that's affecting me.  I starting to come to terms with it but somedays I just miss him so much I can't stand it.  It's also my bad brain chemistry that's affecting me.  I've tried so many different antidepressants and known of them seem to work.  There are days when I just curl up in bed and sleep all day.  I've been missing work over all this and I know it's affecting my job.  I have no ambition to do anything because it's all so overwhelming trying to keep the yard work done, keeping the house clean.  I still haven't cleaned out all of Gene's things and I can't even face the thought of it.  I just don't know where to go from here.