Rheumatoid Arthritis Support Group
Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and...

I always say, be afraid of the damage that RA can do to the body, not the meds that stop the progression of the disease! As for side effects, no one gets all of them, and many times you get none of them. I have been lucky and had only small or no side effects with the biologics I have tried, including Orencia, which I am on right now with Arava and mthx.
Give it time since it can take even up to 2-3 months to work. So don't get discouraged if the added biologic doesn't give you a big improvement off the bat.