This is my experience.I have been on methotrexate since June, 2012 - time flies when you are having fun! :)

I have not lost any hair since I have been on methotrexate. I do not think it is vain to be concerned about how you look. The only issue I did have was my liver numbers went up. The amount of pills I was taking was cut down to 4 a week, and since then, my liver numbers are fine.

Being nauseas has never been an issue for me. I have heard that if it is an issue, if you take it by injection, that might help.

Been on methotrexate for 6 years.....just a few strands of hair fell out (could see them at the drain in the shower). That was probably when I was taking 4-5 pills a week. At two and three pills per week, no hair loss that I can notice. Never had nausea from methotrexate either. We are all different, so I hope your experience will be as good as mine.

Been on Methotrexate for several years now. No problems for me either at low doses. The folic acid should counter side effects, but if not the injectable form should be considered.

My liver numbers have been fine for 4 years now.

Linda

I started Methotrexate about 15 years ago. It made me so nauseous I would have rather been dead. That was what I thought. Then, after just a couple of weeks, I started to get really foamy urine. I asked my doc about it and she had me undergo a number of tests for my kidneys. Come to find out, I had gone into kidney failure.

I had to be under the care of a nephrologist for about three years after that. I will never, ever, ever go near Methotrexate again.

On methotrexate and orencia. No hair loss yet at 6 pills a week. I was told to take biotin to help with possible hair loss.
Good luck

I have been on methotrexate for 14 months, taking 8 pills each week.

I have noticed some hair in the shower drain; but would never suspect I have lost any hair otherwise. I don't find much in the drain these days, and I don't think about it; maybe it slowed down or maybe my husband has been cleaning it out without comment. Those conversations get old after awhile.

I did receive a warning from the rheumatologist's nurse regarding possible hair loss and the suggestion to not dye my hair. I have not dyed my hair this year. I might decide to cover the gray at some point. I wear my hair short and casual. A little gray is not a big deal right now. And I am certainly happy that I don't have to deal with hair loss that is noticeable this year.

I don't get nauseous from the medication. I am careful to eat a full meal before taking the methotrexate, and equally careful not to lay down for an hour afterward.

I am a bit sorry that I did not give injections more consideration at the beginning of this journey, and I did ask the rheumatologist about switching a few months ago (I can't remember my specific reason at the time). But the rheumatologist seemed to remember my squeemish attitude at the mention of needles and injections, because he dismissed the need to discuss switching to injections at that meeting promptly.

Good luck with your personal journey.

Mthx combined with a biologic put me in full remission for 4 years. I would go back on it in a heart beat, if it was not for my liver enzymes going crazy.

I have experienced severe hair loss with prednisone, Actemra and a bit with Xeljanz (or maybe it is the prednisone?) but not with mthx. I guess at this point, hair loss is the last of my worries. Although I admit to crying a few months ago after a shower when so much fell out, I wondered if I would have any hair left.

I had nausea the first few weeks, but it was nothing bad. I will say, the pills destroyed my stomach and they didn't work. But injectable was great.