Myasthenia Gravis Support Group
Myasthenia gravis (MG) is a neuromuscular disease leading to fluctuating muscle weakness and fatiguability. The hallmark of myasthenia gravis is muscle weakness that increases during periods of activity and improves after periods of rest. Although myasthenia gravis may affect any voluntary muscle, muscles that control eye and eyelid movement, facial expression, and...
can anyone explain why we get so overheated------------what are the physiological ramifications that cause the sweating and terrible heat------these "hot attacks" come out of nowwhere and give no warning-----one minute you're fine the next you're soaking wet-----Why?
from the drug sheet on pyridostigmine:
"Pharmacology. Mestinon possesses cholinergic properties due to competitive inhibition of cholinesterase enzyme which normally hydrolyses acetylcholine at the cholinergic synapses and neuroeffector junctions. Thus, the drug causes generalised cholinergic response including increased tone of skeletal and intestinal musculature, miosis, uterine and bronchial spasm, bradycardia and increased secretion of exocrine glands (e.g. saliva, sweat). In addition, pyridostigmine has a direct cholinomimetic effect on skeletal muscle. "