This is interesting to me still, although smoking marijuana or anything else is not optimal for people with MG. We have heard from Norcal Dad around here that he has ingested before. I mentioned it to my Neuro. She didn't want to talk about it only stating about the smoke and lungs issues, because she knows about its action. I wonder if it helped, even though it would be temporary like Mestinon.

I know how it makes me feel when I have tried it in moderation, and my symptoms change. Everything feels good, unless I have to move around, then it becomes a challenge. Not weaker, but cloudy headed? and just heavier feeling, although not weighing me down if I realize and focus on my movements etc.

I think it has properties of acetycholine inhibition and acetycholineterase inhibition, which wouldn't make it any sort of treatment for MG. I know that MG is a peripheral nervous system condition and THC goes to the central, so that would support perhaps Alzheimers for treatment. Huperzine A also crosses the blood brain barrier, which has been said to be effective for MG.

I tried Huperzine A one night, and have never tried it again. I have heard from a few people over time that mentioned it.

Back to THC:

"Several studies have suggested that THC also has an anticholinesterase action which may implicate it as a potential treatment for Alzheimer's and Myasthenia Gravis."

http://en.wikipedia.org/wiki/Delta9-tetrahydrocannabinol

THC, along with Caffeine and Pyridostigimine listed as Acetylcholineterase inhibitors:

http://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor

A study on this:
"Steady-state kinetic analysis of THC inhibition revealed that THC competitively inhibits AChE...This level of inhibition is relatively modest"

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/

I think my conclusion is that trying marijuana is not going to hurt you in moderation, and moderation is the keyword. Used with caution. Many things in moderation can be fine.

"The researchers said it's more difficult to determine if long-term, heavy marijuana use is worse for lungs - because that pattern of smoking was "relatively rare" among the study participants - but they said there was a need for caution and moderation when marijuana use is considered."

"With up to 7 joint-years of life-time exposure, we found no evidence that increasing exposure to marijuana adversely affects pulmonary function," the researchers wrote in study, published in the Jan. 10 issue of the Journal of the American Medical Association. In fact, the researchers found a slight increase in occasional marijuana smokers' lung function. That increase may be indicative of marijuana smokers taking deep breaths and holding the smoke in, the researchers said....

At more than 10 joint-years of marijuana exposure, the researchers saw a slight decline in lung function, but the researchers said that finding was not statistically significant, so could be due to chance. Cigarette smokers, who smoked a median of eight to nine cigarettes per day, saw a significant drop in lung function over the twenty year study. "

http://www.cbsnews.com/8301-504763_162-57356379-10391704/is-smoking-marijuana-bad-for-your-lungs/

Anyone have experience or have something to add about/on this?

TJ