It just depends on how I am doing, some days I am fine when I get up, or I should say not many symptoms, then some days I have to keep laying down to get ready for work...

lovely snow flakes we are...........
Annette

I'm not positive for antibodies either. As my symptoms have gotten worse and more frequent, my mornings have been worse but still far better than the end of the day. But I do occasionally have something like worse speech upon waking if I talked and laughed a lot late the night before, didn't sleep well, basically carried over from the day before. The only time that would improve by the end of the day is if I rest all day and tape my chatterbox mouth closed.

Maybe it would help to keep a journal and figure out if it just happens or if it is unwittingly triggered by something you forgot.

I have RA as well as MG and the morning stiffness makes it hard to tell exactly why I walk like crap after getting out of bed!

I'm taking 60 mg Mestinon every three hours during the day, and I delay my last (6th) pill until I'm ready for bed. I usually don't feel great until late morning after my second dose of Mestinon. I've thought about asking my neuro about taking a timespan at bedtime to see if that would improve my mornings. I've put it off, because I'm still functional in the mornings--it's just that my legs feel heavy, my hips ache, and my arms sometimes feel weak. I'm also seronegative, for what it's worth.

Until recently Mestinon Timespan gave me 12 hours relief overnight. I noticed worsening symptoms after waking, getting about 8 hours from timespan. My neuro has increased my daytime Mestinon dosage to 4 X a day. I notice improvement with this change.
Check with your neuro; a slight change might make all the difference.
Hope you feel better soon.
Larissa

I've been on timespan since last October .it worked great for me. My MG was really bad so i had to take Mestinon as soon as I got up. Now, I'm feeling I need less Mestinon. last night I took 60 mg before I went to sleep last night instead of timespan. I was good through the night, but needed to take 30 mg Mestinon as soon as i got up because I felt weaker. If I exert more during the day,I need more Mestinon. It's also really hot here. If I keep the AC at 71 at night, i sleep better.
As Annette said, we are snowflakes!
Be well,

Thank you for all of your answers! Right now I take timespan at 10 pm, then regular Mestinon 90 mg at 0600, noon, and 5 pm. I was wondering if maybe I was having bad slurred speech in the morning because I didn't need so much Mestinon at the 0600 dose. The speech problem would start at about 7ish and last about an hour or 1.5 hours.

Hi, Erica,
IT could be.... too much Mestinon. something to talk about with your neuro. The only way I figured it out was to let it wear off completely and see how I felt. I'm still figuring it out (LOL) however, it was an aha moment when I went 7 hours one day without it. I had commpltely forgotten to take it because I felt ok. Wish I had more of those days, and it was just one, but I used to be on 90mg every 3 hours, and now I'm between 30-60 every 3 to four (or longer) hours.
Be well,

I have worse mornings, too. If I take Timespan I have awful middle of the nights with cramps. So I take my 60 mg of Mestinon and wait 30 minutes to get up, another 60 with breakfast and 60 at 10:30, 2:00, dinner and bedtime. I think I am helped by prednisone most in the afternoon and evening and sometimes I take a nap. Some days are better than others and even with alternate day taper, I can't say that it is related to that--often weather makes things better or worse. Who knows. :-) I just do better with medication on board and it is lowest in the morning. b.

I totally had worse mornings for a time! I think the Dr.s though I was wacko because this isn't typical. Two years later i don't have this issue anymore. A test that looked for adrenal hormone balance said that I had low cortisol levels in the morning, so perhaps that was my issue. I did notice this trend when I wasn't yet taking Mestinon, so it was easy for me to see that it was just my body's rhythm and not anything to do with how much mestinon I was taking.

I had found many mornings I would feel worse, and then Cathi had suggested that perhaps the Timespan wasn't making it through the night, as they generally only go about six hours. She suggested that when I wake up during the night, try taking 30-60mg of Mestinon. I've tried it, and it works perfectly; and supported also by my Neuro.

I wonder if I can try to play around with my mestinon schedule slightly by myself. The weird thing was that the slurred speech was usually about an hour after my regular am mestinon.

Sounds as though your drug has a short half life.

About 1.75 hours...

Have to agree when I get up during the nite and take mestinon my mornings are better..
Annette