I had issues with my legs first too. I remember having one of my legs give out on me when I was shopping.
I thought I was so wiped out most of the time because of my kids and the fact that I wasn't getting a break!
A lot of times when my Husband would get home I would hit the couch for the night and remember just telling myself to "make it through preparing dinner" (but then I would be too weak to eat it).
My house was getting less and less clean... I felt lazy and exhausted! This got worse for about a year and a half. I looked into fibro, chronic fatigue, depression ... but I was mostly pissed off and frustrated (not sad) and I was achy in my limbs (not in pain). I thought maybe I was getting old. I thought having 3 babies in diapers and two with autism was TOO much to handle.
In March I drove myself to an after hours clinic because I thought I was losing my mind! I was shaking and having trouble breathing and VERY weak! I remember not being able to hold the phone to my ear because my arm and shoulder were aching so badly. I thought it was a major panic attack or anxiety... and so did the doctor. I left with a valium prescription.
It was the next evening that my eye started to droop... and then the next it did it again. I took a picture. Looked online for eye drooping. Found Myasthenia Gravis and thought "that's what my cousin has... so maybe???" Then I kept it in the back of my mind until the end of April when I had a gallbladder attack and had to get it removed right away.
On the way home from my gall bladder surgery my eye fell (the whole side of my face fell). I got on facebook for just a second to tell everyone I was home and doing great. My cousin saw my on there and sent me a message asking how I was. I told her about my bell's palsy reaction to the surgery and she said "If it is gone tomorrow go get tested for MG" It was... and I did!
After taking my first mestinon pill... I could SEE! So my vision had been blurry from the MG for a long time without knowing it was caused by anything other than just not wearing my glasses!

LOL... that was a long answer.... But YES I would say that I had at least a year and a half of general symptoms prior to my droopy eye symptoms!

I think it may have started in my legs and arms to a degree at first, and I didn't notice it right away, which is why my onset time is still up in the air for me, probably by a few months give or take. I really didn't start to notice something was really wrong until my speech went nasal and my breathing from heavy exercise bothered me. It wasn't long after that my legs were noticeable, and looking back my arms were too, but to a lesser degree. Then my eye followed and I noticed one side more than the other was weaker. I was no "muscle man" before MG. My physique still looks the same now. Which I am happy about actually. I am working hard to try to maintain what I got in hopes to be able to get to where I was before onset. No baffling Neurologists for me. Self Diagnosed, after a couple failed attempts by my PCP, who agreed with my diagnoses and blood tested me positively. and sent me along to Neurology.

Best wishes,

TJ

About a month after starting the pyridostigmine, I looked down at my legs and thought--so that's where those muscles have been.
b.

In May of 2009, just before I started looking for an answer to my swallow problems, I realize now I had my first sign of muscle weakness. My little dog got away from me and I chased him (interpretation = I ran like a demented monkey down the street, screaming at him) about 2 blocks. About a block after I started running, my knees started giving out. It was like nothing I've ever experienced, they would just buckle. I did catch my delighted little dog but had to lie in the grass clutching him to my chest until I could get up and slowly make my way back home. I'm sure it was quite a sight. Hind sight really is 20/20.

Mine is my legs as well. Seems to continue to progress even with an increase in meds.

I was diagnosed via lab tests with MG with no ocular symptoms except some blurring. It started with slurring my words more and more as the day progressed. I started out great in the morning but got weaker and slurred more the later it got. I "lost" my smile due to weak facial muscles, had trouble moving food around in my mouth, swollowing got difficult, excessive saliva and my tongue felt too large. Sometimes I was gagging and throwing up bubbles. I had trouble holding my heavy head up but a neck brace helped. My leg and arm muscles became weak and couldn't get out of the tub in the evening but could in the morning. I can't sleep flat on back and need to have my head to one side or the other as something closs at the back and my neurologist says that is due to my MG. The worst though is that I have had several breathing crises where my breathing muscles feel paralyzed however as soon as that happens I take a Mestinon, my husband makes me coffee and massages my front and back breathing muscles and I use the CPAP machine but a BiPAP would be better. That all has helped alleviate the breathing crises within half an hour. Hope this information helps.