No doubt there will be someone out there, but to my mind, the two medications are not really complementary as they do two completely different things and are not dependant on one another. The Prednisone serves to reduce or restrict the antibodies that attack the muscle receptors whereas Mestinon prolongs the action of a neurotransmitter called acetylcholine. Indeed, this is where that fine balance comes from that we often talk about. Now, the controversial bit: The majority of us still have damaged muscle receptors and the generation of antibodies continues, albeit at a reduced rate. That is why we continue to take whatever medication is prescribed.

Not really sure why you ask the questions - we're not masters of our destiny. That is in someone else's hands - for better or worse, it might sometimes seem...

Hi,

i know that you dont like what is going on with your body and mg. unfortunatly this is a very commun happening with all of us and mg.
as i mentioned before , you acn be at the minimum of both meds and do ok.

i am takem the minimum required of mestidone #30 mgs, daily and prednisone 1 every other day, some time i let go couple of days .

mestidone is specificly to control mg,, prednisone a corticoid steriods dedicated for the inmune system, but remember that prednisone gives the body a minimum amount of cortisol, the natural substance that out body produce about 5 mgs, daily

which actualy it is used also to control all infections in the body.

i know you are very set-up in the ways you want to control the meds, and i agree entirely with you

you just have to find the balance of actions and reactions of your body, actualy you will be able to get it right.

the only things that i can suggest to help is, control of stress and emotions, excersises , sports and all others activities, all to be done with mesure, and stop when you fell tired, take a break and maybe laydown 1/2 hr, this will set you up properly.

best of luck

Let me answer the additional question (from my point of view). I guess that I often go down to the minimum levels of both. For about eight years I was on 5mg Prednisone and 30mg Mestinon a day. As Andre has said we naturally produce cortisol (I was told 7mg) but if we take Prednisone the natural process is compromised and may or may not recommence should we reduce Prednisone further. For that reason, I continued to take 5mg, even if I feel just fine. That was the advice I received and it seems good enough for me, given that the alternative is a potential relapse.

Currently, I am still on 5mg Prednisone but had to up the Mestinon, following a bit of a relapse last year, I went through the cycle of increasing Prednisone up to about 40mg each day and back down again. Mestinon went to maybe 5x 60mg in a day, I'm currently down to an average of 3x 60mg and feeling pretty good - so it will gently reduce even further. I'm still on long-term Azathioprine and suspect that I always will be, warts an' all! All by the way, under the supervision of my Neurologist - the only thing I ever vary myself being Mestinon.

Thanks for your input. I guess I will just have to wait and see how things go. I usually give myself a month when I change the meds, so see how I feel at the end of February. Everyone seems to have a different form of treatment and results and you have to find what is right for you. I have bounced back before and if I hadn't broken my arm, I wonder if things would have stayed the same, but I'll neve know for sure; just have to keep on taking it one day at a time for now, but I have been down this road before. It is annoying though, you seem to be doing okay and then it starts up again and you have to start all over juggling the meds. UGH!