I tried it once at night time
hated them so stopped. Not worth the grief.

Since the Timespan is "time released" , I was advised by my neuro not to cut it in half. I couldn't takeTimespan , because my metabolism is slow sometimes. Like you, I was afraid that I would get too much. Mestinon Woes, I call it. You will learn when your body needs a decrease or increase in dosage.

Steve, Timespan is meant to be used at night while you sleep. It should be effective over 7-8 hours. During the day, you take a non-timespan dose (for me-60mg 4x during the day. So for a 24 hour period, I start with a 60mg pill at 5am, 9am, 1pm, 5pm and then at 9pm I take the 180mg timespan..starting over again at 5am with 60mg.....I occasionally have night sweats and leg cramps..but can live with it because taking the timespan allows me to get though the night without having to get up every 4 hours to take a 60mg pill. This has been my routine for over ten years and I've adapted to it. Hope this helps....

I have taken timespan for a couple of years now. At first I took only half a tab because I was afraid of over medication. My have developed more tolerance for it, so have been taking the whole thing for more than a year.
You can break them on the score with no problems.
Here is a link, if it works, to a previous discussion of this issue.

http://www.dailystrength.org/c/Myasthenia_Gravis/forum/15877436-those-timespan-mestinon

Is there any possibility that your timespans have been exposed to humidity or moisture? I bring this up because the matrix of the pill breaks down very quickly in any humidity at all, and that could cause the medication to release too quickly. I've taken to putting the closed bottle inside an airtight tupperware just to keep the pills from breaking down.

I was originally just on the normal Mestinon, but due to still being in school, it became too much of a hassle to leave class every few hours to take the tablets, and some teachers wouldn't actually let me leave for said purposes, so my neurologist put me on the time span tablets. It had it's benefits obviously, but after a little while, it became obvious that I was over medicating with it. I had horrendous twitching episodes and that effected my schooling even worse as the hand twitches could last up to 20-30 minutes so I couldn't actually write - not to mention the looks I got from it. I also had really bad eye twitches which made it even harder to study. SO I feel your pain in relation to over medicating with it.
Have you and the doctor talked about different methods of dealing with the MG, as your doctor should try to make you as comfortable as possible, and clearly this method isn't working for you, so maybe your doctor has a different/better idea of managing the condition.
I was offered either the mestinon or steroids and was put onto Immunoglobulin (not sure if that's the spelling) infusions. I chose the mestinon as I didn't want the side effects that came with the steroids, so there are other options besides the mestinon, but just talk to your doctor and see what other treatments options that are available for you.
I really hope that you sort this out soon, it's an absolute nightmare over medicating and under medicating! I am just thankful that I am currently in remission! I hope that lovely sounding word graces your ears soon!

Seattle Writer, I had to educate my pharmacist on that. He was taking them out if the original packaging that has the little absorbant cylinders and putting them in regular containers and they got all dark and stuck together.

I tried timespan mestinon overnight and gave it up. It was much more expensive and my insurance made me pay $80 for a bottle vs $10 for the regulars and it didn't really help me the way I wanted it to.

I wanted to wake up with the mestinon in my body ready to go rather than wake up and take the first pill and wait for 30 minutes to be functional. It did do that, but at the bother of overnight over cramps, twitches and bathroom trips. Waking up at 1 am with a severe agonizing foot, leg or thigh cramp and spending a half hour trying to ease it out, is not my idea of a good night's sleep!

Using a CPAP to help with breathing made it so I didn't need overnight mestinon. I took a regular mestinon pill 1/2 hour before getting out of bed and that got me functional. Eventually with prednisone, I gave mestinon a not-so-fond farewell.
Good Luck
Russ

Thank you everyone for the great tips, especially on how to keep the timespan pill dry. I'm well familiar with the humidity problems.

I do have a routine now! I take a 60mg when I get up, then 3 hours later take a 180mg timespan, then in the evening take half a timespan for sleeping.

I do like the timespan during the day, and did not realize until recently how much better and effective a fresh, dry timespan works vs. the gummy, exposed, moisterized timespan - which is not good at all.

Just a comment - timespan is not available in the UK - the reason - NICE (= our FDA) wouldn't pass it as efficacious for exactly the experience you are having.

It was found not to be slow release, delivering too large a shot of Mestinon in the early part of the night and insufficient by morning,

I know people here wh just set their alarm for every 4 hours and take 60mg every 4 hours during the night - inconvenient but effective.

Steve~~Cut the timespan in half and see if that helps.They are scored down the middle and I think that makes it okay. I can't tolerate a full 180 timespan -- my digestive system dissolves them very quickly and I get jittery from too much anti-cholinesterase. ~Joe

I take timespan at night and while I do sweat I find it helpful. Mind you, I thought the sweating was due to menopause so it did not bother me that much. I am used to kicking off the blankets and then reaching for them five minutes later.

I find they help my significantly for getting out of bed. Mind you, I am feeling a lot better these days and its hard to tell whether I am just improved from when I was in crisis or if its the meds. Probably a combination of the two.

I hope you work it out.