Unfortunately steroids can put you on an emotional roller coaster ride, especially with high doses. My relationship with prednisone was so bad at one time that I sought a new neurologist, and he switched me to methylprednisolone, a steroid given once per week. Taking my steroid once per week limits insomnia to one night per week. To minimize insomnia further, I wake up very early to take my med's before going back to sleep. The emotional rush is also limited with this dosing method. I read of many prednisone woes but rarely do I see that people seek out different steroid options, which exist! I am so sorry you are dealing with the wild fluctuations of disease and side effects, which are too common with MG.

How I felt and still feel your pain, sister!!! I called my husband crying so hard I could barely talk because I had just left the neuro's office after being told I had to stay on the prednisone. I told him I just couldn't take the horrible depression, mood swings, and overall personality change. Really felt I was losing my mind.
Things have gotten much better as they will for you, too! I still have major sleeping issues on 5 MG a day but the rest is so much better.
Take it one day at a time....it will get better! I am still on this day to day coaster ride but when the pred symptoms calm down it is much easier to cope. Sending love and hugs your way-Brenda

Gosh, I'm really sorry that you are having such a hard time emotionally. It's not easy. That's for sure. As others have said, there are other dosing options and different types of steroids that could improve your mood issues. I am taking only 2 antidepressants now (down from 4, earlier this year) and I think that the Cymbalta that I was put on recently for the fibromyalgia has done wonders for me. Having been told recently by my neuro that, "You'll be on the prednisone for the rest of your life. Taking you off of it has caused exacerbations twice now and I refuse to take that chance again with you." He also said that he will not go any lower than 10 mg per day because that's when my breathing tanks and my legs and arms refuse to work anymore. It's a grim reality but it's my reality to I have to suck it up and learn to live with it. Perhaps you would benefit from a mild antidepressant. You should discuss it with your PCP or Neurologist to get their feedback. It's worth a shot if you are willing to try it. I would also discuss the Methylprednisolone or the alternate dosing options. There are antidepressants that can help improve the sleep issue too. That's double the fun... hehehe. Try to keep pushing on and remember to find something each day to make you smile. I hope it improves quickly. Hugs!!
Angie

Hope you are doing better, Elle.
I wonder how many of our neurologists - are aware of the positive correlation between prednisone - and lousy sleep.
Yes - if you stay on prednisone, take it as early in the day, as possible.
If you can, get some mild cardiovascular exercise.
Don't do anything, to antagonize any medical condition.
But even a couple of slow, 5-minute walks - can help you sleep better.
Wish I'd known this, long ago.
That's not my Neuro's fault, he has always encouraged mild-exercise, when possible.
I like the idea - of discussing other forms of prednisone - with your Neuro. - Ross

When I mentioned the crying and depression, I was asked if I felt like I was going to go postal (do you think people answer that question honestly?). When I said no was told chances were good that it was the prednisone. He could give me something but suggested I wait until it either got worse or better. I'm down to 30 mg now (and will prob be lowered more next week). I no longer cry when the cat looks at me, so I guess that part is getting better, hopefully it stays that way. So I can agree with everyone saying the prednisone is prob the cause and that will get better. Hugs and prayers for you. If you need to talk feel free to message me.
Pam
ps.....I had actually told my friend I was thinking about going to the hospital for a 72 hr eval before the crying started slowing down.