I'v been on Tecfidera for about 6 months now and as far as I can tell everything with me is still on track, I mean I have more problems' with walking and hurting but I just chop it up as the monster MS
I have an appointment about the middle of the month and I'm sure the doctor will be ready to do an MRI to check if there are any differences since last time. Otherwise twice a day works for me.

Good Luck

I just started Tecfidera in January and I see my Neurologist in May to see if it is working. It has been giving me bad stomach cramps and nausea. I would ask your Neurologist about the leg pain. I have constant leg pain anyway so I don't think the Tecfidera has anything to do with it. Good luck friend

I do not think that it works as well as Rebif did.

These are my problems I get with Tecfedera:

1. Constipation and gas. I get constipation that I swear i get from Tecfedera although my neuro doesn't and the fact sheets don't say that it is a cause. But my problem with constipation is worse now on Tec and when I skip a dose, it gets better. Definitely, think that it can add to my problem. PLUS, I get gas that is a problem in crowds! I have never had problems with diarrhea at all with Tec or stomach cramps.

2. I have problems with my feet getting tingling feelings that I never got before until I got on Tec. Also, my walking is slower and worse. I haven't fallen lately but my walking is worse. I feel my MS is growing in my legs. I get weird feelings in my legs that I got before when I first got MS and it meant my MS was moving around in my body. My MS is progressing with Tecfedera. My disability is more noticeable by other people and they are treating me like I can't open a door, etc., which is far from true. But other people are noticing my progression. Ugh.

3. I don't get the worse days that I had on Rebif and all the problems from the scar tissue from the shots but Rebif seemed to work better. I see my neuro in April and will ask him to put me back on Rebif.

I switched from Rebif because I was no longer eligible for patient assistance, eventhough I have the exact same financials, was on Rebif from 2003-2012. With Tecfidera I have had flushing twice but it came & went fast so really not a problem. I have had some GI issues but nothing horrible. If I eat a pc of bread before the pill there are no side effects for me.

I have been taking Tecfidera since Jan 2014. It started out very smooth but when I got to week 3 I thought I might have quit. I had some major stomach pain (not nausea but real pain) and flushing that was really bad.

I made it thru and I am glad I stuck with it.

I have had some random itching of the palms of my hands and bottom of my feet but have not had that in last 3 weeks or so. When I do it goes away so quickly I forgot all about until someone ask about side effects.

I have had about 3 or 4 episodes of flushing since week 3 but each have been extremely mild and last about 10 mins.

Some times I have insomnia but I don't know if it is related because I randomly had bouts with it before Tecfidera.

I also have high hopes for the drug. For me I think I was getting needle fatigue and having this oral option is better not taking a DMD at all.

I have my 3 month check up in a few weeks and right now I would say we will continue with Tecfidera.

After I was bumped up to the two pills a day, the bad gas began and major bloating. I noticed, too, that my legs were getting worse. It really did seem as if my MS was progressing and it was scary! I called the Acreedo pharmacy to ask them if the leg issue was something they were hearing about. The pharmacist acted as if I just arrived from the moon. I had seen other Tec folks on other boards talk about leg issues and I mentioned that. He told me that what is talked about on these boards should be taken with a grain of salt. I was not amused. The people on these boards are relating real experiences! I digress. After talking to my neuro about my issues, he put me back to 1 pill a day for 3 weeks. It helped with the bloating and gas, but the legs were still a bit of an issue until recently. (Not sure what happened there, but they are better.) Anyway, after the 3 weeks, I was back on 2 pills and everything came back-the bad gas and bloating. So I'm back to 1 pill and seeing him the end of March. We'll see what he says. If the 2 pills a day is messing with my legs, I don't want that!

Please tell your pharmacist that supplies your Tec about what you are experiencing with your legs or any other issue. It might help all of us on Tec in the long run.

I started Tecdifera on March 3, 2014. The first week was fine. I am on the second weeks now and i am itching. I was thinking on taking benadryl, but i don't know if that is something u would take. Its madness. I don't break out. just itching.

Thank you everyone for your replies! :) I guess we will have to see how we do over time. I am sorry for all who mentioned problems with their legs. I hope we all see some improvement. I have been a feeling little better. I have an MRI in two weeks and an appointment with my neuro soon after. I am curious to know his thoughts.

Sending everyone good wishes.