Hi, i have been on rebif for about 7 months and i was prepared to be miserable and to be sick all the time, not the case at all for me! i heard that it was such a big deal and i did not have any trouble with any of it , now i know that some do! im not trying to make light of the side effects but i was expecting for it to be awful and i was so pleasantly suprised, not sure if its helping , now thats another story.

I have never been on Rebif, but I did take my injections on Friday nights like your nurse suggested. I lived for months with no life, because of the side affects from the Avonex. Monday couldn't come fast enough for me I was so darn sick. I couldn't live with a lousy quality of life anymore, and chose quality over quantity. I switched to Tysabri. I hope you are going to one of those that don't experience any side affects. Hope you get lots of responses too.

Hey there!
I've been on Rebif off and on for a year. I had flu symptoms sometimes, a couple of really high fevers/chills after I started and re-started. I had site reactions just redness and bruising but I think it was because the needle wasn't going deep enough.

I got very depressed too. I'm sure it was related to the MS as much as the drug but since I have been off it I have been feeling great. The problem I had was that I was still showing new and active lesions while on it so it wasn't for me. I tried Copaxone for a month but the site reactions with that were un-bearable. I'm not on anything right now because my husband and I want to try to have another baby while things are stable. I hope the Rebif helps you but it just wasn't the one for me.

Good luck and write me anytime if you have questions.

*Hugs* Trish

I am on Rebif as well I started on A Wednesday as thats the day the mS nurse came out 8.8mcg I had no side effect with it.Well other than a red area a couple days after the injections.The 22mcg I only started last week so far so good.I do use a ice pack to dumb the injection site for a couple of mins......that helps I also use hydrocortisone cream with a cotton ball to massage the area after injection as well.About 30 mins before injection time I take a Advil.As far as any side effects I am tried the next morning...I hope this helps.Good luck
(((hugs)))

Thank you all for your responses! One more question...where is the best place to inject? I'm worried about the site reactions. This whole thing is pretty terrifying! It's hard to go from hardly ever taking medications to having to give yourself shots 3 times a week!

Hi Meg,

I'm starting my fourth month of Rebif and am happy to say I have had no side effects except for the second month of the 44 shot and than it was just a fever and it could be control'd with Aleve or Ibuprofen. After that I've had no problems.
As far as injection site make sure you rotate like they want, you have 4 different spots on each side of the body. I read where some people use on a couple of sites but for me I don't want to take any chances as it would be to easy to keep injecting into the easy spots on your body.
I just want to wish you good luck and remember to premedicate just make sure there is not that little drip of Rebif on the needle before you inject because if there is it sometimes makes for a bad experience and no one wants that.
Take Care and Good Luck
Dave