I did not experience depression from a side effect of Rebif. I did however get really achy and feverish is I didn't take some Aleve about 1/2 hour prior to the injection. I also did my shot in the evening before bedtime so I could sleep through the worst of it. Sometimes I would still feel bad the following day. Sometimes I didn't.

I would have been fine with continuing with Rebif if it worked well for me but unfortunately I got new lesions while on it so I was switched off of it. It just didn't work with my system but might be just fine for yours. :-)

Best wishes!!

All of the interferon's can cause depression from what I understand. When I started on Betaseron, my doctor monitored me to make sure I didn't get depressed.

If the medication works for you, your doctor may have you start an antidepressant (it's better to stick with something that will slow the disease and medicate the side effects than to not take anything at all). Your doctor may also switch you on to Copaxone.

I would stick with rebif until you have been on it long enough for it to reach it's full effectiveness unless you find you are suicidal...

It's also hard to determine if you are depressed because all of this horrible stuff has happened to you, if having to take give yourself a needle regularly is depressing, if the change in lifestyle is making you depressed or if it's the medication itself.

Please call your doctor and see what he has to say.

Honestly I'm not sure what is going on with me, I do know its not a needle phobia use to that. I was just curious and my concern regarding depression meds is weight gain(yes vain I know) but it has taken me a long time to make my weight progress I will NOT gain weight for an antidepressant. LOL

My mom started taking Bupropion as an antidepressant because it is one of the medications least likely to cause weight gain and it doesn't have some of the horrible side effects that the SSRIs have.

Try reading this article http://health.msn.com/health-topics/depression/articlepage.aspx?cp-documentid=100144756

If you talk to your doctor about an antidepressant go in with a very clear picture of what medication you want, and why you want it.

I've been taking Rebif. for over 2 yrs. now. No new lesions since. It seems to be working for me. I do have to inject around the redness that sometimes lasts over a Wk. I do have 81yr. old skin so that may be part of the problem LOL And no, i have not had depression. You should discuss depression with your Dr.

Best wishes

I experienced massive depression. The only way I was able to determine that it was the Rebif, was to stop taking it. Depression medication did no good, so my doctor switched me to Copaxone, which does NOT have this side effect.

Like rickt51, I suffered from SEVERE depression on Rebif. I tried every anti-depressant know to man and nothing helped.I had a little vacation from Rebif and was switched to Copaxone. Of the CRAB drugs, it's the only one that's not an interferon, and therefore doesn't cause depression. Also, the injections don't feel like acid being injected into you. Best of luck to you!

I have been surprised about the injections no red spots no pain what so ever or it could be that I leave the rebif out all day before taking plus use to needles no big deal, however this doom feeling is on me not as bad comes and goes, I will keep on pushing and see how am doing at the higher dose before I decide to medicate or deal with.