Multiple Sclerosis (MS) Support Group
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Usually docs want at least 2 complete trials with conclusions before they will prescribe for you. If all the current meds are not working which means you are a more likely need to try something new to TRY to help you.
Riluzole is well established at reducing glutamate in ALS and is one of there best drugs against this disease. See following on how ALS is like MS including high glutamate which is the target of this drug Riluzole. http://www.jneuroinflammation.com/content/9/1/20
NIH research of Riluzole on MS all seems positive.
1.) http://www.ncbi.nlm.nih.gov/pubmed/15949499
Extracellular accumulation of glutamate contributes to excitotoxic injury of neurons and glial cells, suggesting that the maintenance of subtoxic extracellular glutamate levels may be crucial. Riluzole is a neuroprotective agent that inhibits the release of glutamate from nerve terminals and modulates glutamate, i.e., kainate and NMDA receptors. It inhibits excitotoxic injury in several experimental models of neurodegenerative disease. We performed a small run-in versus treatment MR-monitored pilot study in 16 primary progressive MS patients. The results suggest that riluzole reduces the rate of cervical cord atrophy and the development of T1 hypointense lesions on magnetic resonance imaging in primary progressive MS. The rate of brain atrophy was only slightly decreased. The results indicate an effect on mechanisms involving lesion evolution and axonal loss, but no clear effect on new lesion formation. However, the data suffer from several limitations and must be confirmed in future trials.
2.) http://www.ncbi.nlm.nih.gov/pubmed/14556941
In conclusion, our study demonstrates, for the first time, that riluzole can reduce inflammation, demyelination and axonal damage in the CNS and attenuate the clinical severity of MOG-induced EAE. These results suggest that riluzole, a drug used in amyotrophic lateral sclerosis (ALS), might be beneficial for the treatment of MS.
http://clinicaltrials.gov/ct2/show/NCT00202397
Phase 2 trial done
Best wishes to all,
EP
Riluzole is well established at reducing glutamate in ALS and is one of there best drugs against this disease. See following on how ALS is like MS including high glutamate which is the target of this drug Riluzole. http://www.jneuroinflammation.com/content/9/1/20
NIH research of Riluzole on MS all seems positive.
1.) http://www.ncbi.nlm.nih.gov/pubmed/15949499
Extracellular accumulation of glutamate contributes to excitotoxic injury of neurons and glial cells, suggesting that the maintenance of subtoxic extracellular glutamate levels may be crucial. Riluzole is a neuroprotective agent that inhibits the release of glutamate from nerve terminals and modulates glutamate, i.e., kainate and NMDA receptors. It inhibits excitotoxic injury in several experimental models of neurodegenerative disease. We performed a small run-in versus treatment MR-monitored pilot study in 16 primary progressive MS patients. The results suggest that riluzole reduces the rate of cervical cord atrophy and the development of T1 hypointense lesions on magnetic resonance imaging in primary progressive MS. The rate of brain atrophy was only slightly decreased. The results indicate an effect on mechanisms involving lesion evolution and axonal loss, but no clear effect on new lesion formation. However, the data suffer from several limitations and must be confirmed in future trials.
2.) http://www.ncbi.nlm.nih.gov/pubmed/14556941
In conclusion, our study demonstrates, for the first time, that riluzole can reduce inflammation, demyelination and axonal damage in the CNS and attenuate the clinical severity of MOG-induced EAE. These results suggest that riluzole, a drug used in amyotrophic lateral sclerosis (ALS), might be beneficial for the treatment of MS.
http://clinicaltrials.gov/ct2/show/NCT00202397
Phase 2 trial done
Best wishes to all,
EP
gasf
Meant provocation with DMSO & EDTA. The mercury and lead didn't show up until after provocation and my mercury even after having all my mercury fillings removed was off the charts.
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