After an itchy skin reaction to a Rebif shot one month ago, my neurologist is thinking I might have an easier time on Avonex. My problem is that I am very small, most of my injections sights have hard lumps and makes injecting difficult. My other problem is I don't have a ton of muscle either. I was wondering if the Avonex shots do not cause hard lumps under the skin and would it really be easier than the Rebif? And what does it do to your muscles? Does it do damage to them, long term? I'm 5' 4'' and 106 lbs, so as my doc said, I don't have a ton of real estate. Any information would be greatly appreciated. I do manual injections. Is that how you have to do the Avonex? Has anyone done both and how did they compare for you- shot wise and disease wise. And how were your reactions to it? I've only been on the 22mg dose of Rebif so it will be just slightly more per shot of the Avonex. I've never had a reaction to it, does that mean the Avonex would be the same? Thanks