Multiple Sclerosis (MS) Support Group
This community is a place where members can discuss current events and weigh in on what's going on in the world.
in the journal Medical News, they reported on April 29, 2011
that the med Aricept that is used for cognitive decilne in Alzheimes failed to improve memory in MS.
http://www.medpagetoday.com/clinical-context/MultipleSclerosis/26203
you might have to sign up for a free membership to view the article.
this is how the article starts....
The acetylcholinesterase inhibitor donepezil (Aricept) failed to improve multiple sclerosis patients' memory impairments in a placebo-controlled, multicenter trial, researchers said.
Neither patients' impressions of memory function nor their scores on an objective test of verbal memory -- the two primary outcome measures in the 120-person trial -- were better after 24 weeks of treatment with 10 mg/day of donepezil, reported Lauren Krupp, MD, of the State University of New York at Stony Brook.
The treatment also had no statistically significant benefits on secondary endpoints, although there was a trend favoring improvement in clinicians' impressions of change, she and her colleagues wrote in the April 26 issue of Neurology.
The findings, although disappointing, were not entirely unexpected, the researchers indicated.
"Cognitive impairment affects 40% to 60% of individuals with MS, and no medication has been consistently shown to be effective for this problem," they wrote.
On the other hand, an earlier randomized trial with donepezil conducted in 2004 by several of the same researchers had found a modest benefit.
In the new report, Krupp and colleagues argued that the drug may still be beneficial in MS-related cognitive impairment -- just not strongly enough to be reliably detected in a 120-patient trial.
that the med Aricept that is used for cognitive decilne in Alzheimes failed to improve memory in MS.
http://www.medpagetoday.com/clinical-context/MultipleSclerosis/26203
you might have to sign up for a free membership to view the article.
this is how the article starts....
The acetylcholinesterase inhibitor donepezil (Aricept) failed to improve multiple sclerosis patients' memory impairments in a placebo-controlled, multicenter trial, researchers said.
Neither patients' impressions of memory function nor their scores on an objective test of verbal memory -- the two primary outcome measures in the 120-person trial -- were better after 24 weeks of treatment with 10 mg/day of donepezil, reported Lauren Krupp, MD, of the State University of New York at Stony Brook.
The treatment also had no statistically significant benefits on secondary endpoints, although there was a trend favoring improvement in clinicians' impressions of change, she and her colleagues wrote in the April 26 issue of Neurology.
The findings, although disappointing, were not entirely unexpected, the researchers indicated.
"Cognitive impairment affects 40% to 60% of individuals with MS, and no medication has been consistently shown to be effective for this problem," they wrote.
On the other hand, an earlier randomized trial with donepezil conducted in 2004 by several of the same researchers had found a modest benefit.
In the new report, Krupp and colleagues argued that the drug may still be beneficial in MS-related cognitive impairment -- just not strongly enough to be reliably detected in a 120-patient trial.
-
My 6mo twin DD's are EBF and just started rice cereal on the first. Everything has been going fine except this morning one of them had a diaper rash (lots of redness around her anus). I read this as one of the signs of an allergy. BUT I did just buy a different brand diaper yesterday (which they have used randomly before w/no issues). Do you think its the cereal or the diaper? Im ready to start...
Thanks for posting this news. Very interesting!
i would like it better if they found a med that helped MS cognitive issues.
my grandmother died with alzheimers, so of course i was worried about i might get alzheimers..6 years ago i read a study that said alzheimer is lower in the MS population than in the general population, so something about MS may protect a person fro getting alheimers--i just looked at this study of an alzheimers drug noyt working in ms & i thought GREAT! :) more evidence that MS is not alzheimers.
L-amphetamine sulfate was associated with improved learning and memory and was well tolerated in this study. However, because the positive findings were observed on secondary outcome measures, the study requires replication before L: -amphetamine sulfate can be recommended for the treatment of cognitive impairment in MS.
http://www.ncbi.nlm.nih.gov/pubmed/19263186
Adderall
http://en.wikipedia.org/wiki/Amphetamine