Multiple Sclerosis (MS) Support Group
This community is a place where members can discuss current events and weigh in on what's going on in the world.
http://news.yahoo.com/s/usnw/20100628/pl_usnw/DC26883_1;_ylc=X3oDMTEwamZqc2p0BF9TAzIwMjM4Mjc1MjQEZW1haWxJZAMxMjc3NzQzNzA0
Sixty-Two Year Old Chemotherapy Treatment Shows Promising Results on Progressive Multiple Sclerosis Patients
NEW YORK, June 28
Study shows ITMTX may have beneficial role in progressive forms of MS
NEW YORK, June 28 /PRNewswire-USNewswire/ -- The Multiple Sclerosis Research Center of New York (MSRCNY), together with the International Multiple Sclerosis Management Practice (IMSMP), today announced that results from its Intrathecal Methotrexate Treatment in Multiple Sclerosis study have been published in this month's issue of Journal of Neurology. This study reports on the feasibility of using intrathecal methotrexate (ITMTX) in treatment unresponsive multiple sclerosis (MS) patients with progressive forms of the disease.
A retrospective, open-label, chart review analysis was conducted following patients with MS for up to eight treatments. Patients were considered for ITMTX treatment if they were unresponsive to or intolerant of FDA approved treatments. There was a one year follow-up after their eighth or last treatment. Patients underwent neurological assessments and expanded disability status scale (EDSS) evaluations. In 87 secondary progressive MS patients, EDSS scores were stable or improved in 89%, with significantly improved mean EDSS post-treatment compared to baseline. Of 34 primary progressive patients, EDSS scores were stable in 82%, with no significant progression in EDSS post-treatment compared to baseline. ITMTX may have a beneficial role in progressive forms of MS and is well tolerated with no serious adverse events.
"We have opened an avenue of treatment for an otherwise untreatable form of MS," said Dr. Saud A. Sadiq, Director of the IMSMP/MSRCNY and the study's lead author. "This is exciting news because it's the first time a treatment has been shown to be effective in the late stages/progressive forms of MS."
About Methotrexate
Methotrexate (MTX), an antimetabolite, has been in clinical use since 1948 when it was found to produce temporary remission of acute childhood leukemia. Because of its indirect immunosuppressive effects, MTX is used in treating autoimmune conditions such as rheumatoid arthritis and psoriasis.
[ME--I think its used in Crohns treatment too????]
Sixty-Two Year Old Chemotherapy Treatment Shows Promising Results on Progressive Multiple Sclerosis Patients
NEW YORK, June 28
Study shows ITMTX may have beneficial role in progressive forms of MS
NEW YORK, June 28 /PRNewswire-USNewswire/ -- The Multiple Sclerosis Research Center of New York (MSRCNY), together with the International Multiple Sclerosis Management Practice (IMSMP), today announced that results from its Intrathecal Methotrexate Treatment in Multiple Sclerosis study have been published in this month's issue of Journal of Neurology. This study reports on the feasibility of using intrathecal methotrexate (ITMTX) in treatment unresponsive multiple sclerosis (MS) patients with progressive forms of the disease.
A retrospective, open-label, chart review analysis was conducted following patients with MS for up to eight treatments. Patients were considered for ITMTX treatment if they were unresponsive to or intolerant of FDA approved treatments. There was a one year follow-up after their eighth or last treatment. Patients underwent neurological assessments and expanded disability status scale (EDSS) evaluations. In 87 secondary progressive MS patients, EDSS scores were stable or improved in 89%, with significantly improved mean EDSS post-treatment compared to baseline. Of 34 primary progressive patients, EDSS scores were stable in 82%, with no significant progression in EDSS post-treatment compared to baseline. ITMTX may have a beneficial role in progressive forms of MS and is well tolerated with no serious adverse events.
"We have opened an avenue of treatment for an otherwise untreatable form of MS," said Dr. Saud A. Sadiq, Director of the IMSMP/MSRCNY and the study's lead author. "This is exciting news because it's the first time a treatment has been shown to be effective in the late stages/progressive forms of MS."
About Methotrexate
Methotrexate (MTX), an antimetabolite, has been in clinical use since 1948 when it was found to produce temporary remission of acute childhood leukemia. Because of its indirect immunosuppressive effects, MTX is used in treating autoimmune conditions such as rheumatoid arthritis and psoriasis.
[ME--I think its used in Crohns treatment too????]
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My 6mo twin DD's are EBF and just started rice cereal on the first. Everything has been going fine except this morning one of them had a diaper rash (lots of redness around her anus). I read this as one of the signs of an allergy. BUT I did just buy a different brand diaper yesterday (which they have used randomly before w/no issues). Do you think its the cereal or the diaper? Im ready to start...
http://www.news-medical.net/news/20100628/ITMTX-treatment-effective-in-late-stagesprogressive-forms-of-MS-Study.aspx