I sometimes have issues trusting friends -- especially if they are being distant or seem upset with me.

I used to be much more confident in my friendships (and relationships in general) but in recent years I've developed some anxieties around close relationships. When I have feelings like yours I tend to question them because I am conscious of my own insecurities. If there is no apparent reason the the friend would be upset with me I assume it not me and that usually helps with the negative thoughts.

I also try to focus on the friend and see what could be causing his/her reactions other than me -- i.e. Stressful day at work/school? Death in the family? Problems with the significant other?

It's also OK to ask talk to the friend. Don't grill them or ask a million questions. If they say everything is good, move on. Insecurities are unattractive.

of course. I have never had a friend stay with me longer than four years in a row. I've had falling outs and getting back together with friends, but ultimately they all end the same - gone. And the more I am alone, the more I see others keeping friends and making new ones so easily, the more I find myself turning inward and thinking what I've done wrong. The problem is when you haven't done anything wrong, but the people you've made friends with don't have common ground with you anymore. All you can hope for is a new start and another chance at making friends...a clean slate.

My mind is full of negative thoughts when I am alone talking to myself.When I am around people, I am talking to myself too.My frineds cannot make me feel better.Only if she is special.

sounds so much like me...............

Greetings
First of all, I haven't offer online supports for some years, so if you find the words are less comforting, my apology.

I can only imagine what manner of thing(s) that you have shared with your so-called friends. Either the matter was too sensitive or inappropriate, they choosed to ignore you, and a sense of lonliness remain as the result (I can only guess). But think carefully, was the topic being shared with the right person? In other words, were they worthy of the slightest initmacy or privacy of yours?

I used to think that the world in general is cold and sensless because no one was kind enough to talk to me. And for a while, I too thought negatively about human in general. But my mentor had shown me, that most of the time people are wrapped up with their own sorrow, and forgot about the fact that they may have met a number of individuals who are just as sad as themselves everyday.

Young man, people are changable. They ignored this time does not mean that they choose to ignore you forever. And if you want to find a true friend to share things with, do so with an open heart and ears. Listen and feel.

Lets not to dwell in the negative thoughts, there are still good people waiting for you to reach out. And when fate come by, you can surely find a friend for life!

Good Luck