Hepatitis C Support Group
Hepatitis C is a blood-borne viral disease which can cause liver inflammation, fibrosis, cirrhosis and liver cancer. The hepatitis C virus (HCV) is spread by blood-to-blood contact with an infected person's blood. Many people with HCV infection have no symptoms and are unaware of the need to seek treatment. Hepatitis C infects an estimated 150-200 million people worldwide.
Umbilical Cord Blood Derived Stem Cells Used to Treat Liver Disease
July 11, 2008
A collaborative study conducted by a group of Spanish scientists from the University of Granada and Leon has concluded that mononuclear blood cells derived from the human umbilical cord blood can be used to treat liver disease, such as hepatitis. The study results will be published in the upcoming issue of Cell Transplantation.
Luis G Fontana, lead scientist working at the Department of Biochemistry and Molecular Biology, University of Granada, and colleagues, introduced human umbilical cord blood cells (HUCBCs) through the hepatic portal vein of D-galactosamine-induced hepatitis mice models. The analysis of enzymatic activities of various liver enzymes, including alkaline phosphatase, alanine transaminase, lactate dehydrogenase and gamma-glutamyl-transferase, as well as monitoring of total and direct bilirubin levels, demonstrated a significant improvement in both histological damage and the hepatic function of the rats following cell transplantation.
In an earlier research, Xiuli Wang and coworkers (Blood, 2003) transplanted highly purified CD34+CD38-CD7- human hematopoietic stem cells obtained from umbilical cord and bone marrow, into immunodeficient mice, to evaluate the efficacy of the stem cell-based treatment strategy for liver disease. One month after the transplantation procedure, the mice models were induced with liver damage and hepatocyte proliferation by administering carbon tetrachloride (CCl4). The researchers observed increased expression levels of human-specific albumin mRNA and protein in the serum of CCl4-injured mice models, one month post liver damage. However, the scientists documented the lack of human albumin in mice that did not receive transplantation and in noninjured controls transplanted with the stem cell population. The study indicated the development of albumin-expressing hepatocyte-like cells in the liver of immunodeficient mice, suggesting the use of bone marrow and umbilical cord stem cells as an effective treatment strategy for liver diseases.
The term hepatic or liver disease denotes a broad range of conditions or disorders that affect the structure or proper functioning of the liver. There are diverse causes for liver diseases including viral infection, injury, genetic defects, and exposure to drug or toxic compounds. Nausea, vomiting, reduced appetite, jaundice, low-grade fever, muscle pain, and fatigue are some of the common symptoms associated with different types of liver diseases.
According to the 2007 report of the American Liver Foundation (ALF), one in ten US individuals are affected with liver diseases. Hepatitis, cirrhosis, hepatic carcinoma, alcohol-related liver diseases are some of the commonly occurring hepatic diseases. Liver transplantation is the only treatment modality for patients with end-stage liver diseases. As per ALF, the number of patients undergoing transplantation has increased rapidly in recent years, and currently around 17,000 Americans are awaiting surgical treatment. Stem cell therapy, using bone marrow or umbilical cord cells, could be an effective alternative for liver transplantation in treating irreversible liver dysfunction and also for managing other chronic hepatic diseases.
References
1. Scientists use stem cells from the umbilical cord to treat hepatic diseases. Press Release. University of Granada. Last accessed on July 9, 2008.
2. Wang X, Ge S, McNamara G, et al. Albumin expressing hepatocyte-like cells develop in the livers of immune-deficient mice transmitted with highly purified human hematopoietic stem cells. Blood. Online Publication. January 30, 2003.
they are doing it over here in some cases. i'm gonna go ahead with my appt and will get back to you with further info after that.
take care my friend
x
cant wait for the future!!
I am very interested.
Is this approved?
Don't tell me you know Micheal J Fox, and Tom Cruise personally, lol.
I know your dear President here in the States was totally against these celebraties when they talk about stem cells, and what M.J.Fox is working on.
Thanks again, for your always interesting posts my love.
Yes we need to continue to learn anything and everything regarding this virus, this is the only way we can challenge the death of this bloody virus.
KNOWLEDGE IS POWER!
Mckenzie
One day at the time.
i will keep you updated when i have more info to hand.
take care hon and be happy:)
x