Hi, I don't know anything about your circumstances but my understanding is that for noncirrhotic treatment-naive if you:

"remained detectable at any visit from
week 8 up to but not including week 24 (i.e., a slow
virological response), BOC was discontinued and the
patient received SOC treatment for an additional 20
weeks"

which including the lead-in would mean 48 weeks.

This is from the AASLD treatment guidelines. I have it as a pdf so hang on and I'll go find a link...



under 100 at wk 12 and UND at wk 24 then you complete all 3 drugs to wk 36 then SOC till wk 48 (ie 32 wks BOC).

protease, boceprevir (BOC) and telap-
if, how-
ever, HCV RNA remained detectable at any visit from
week 8 up to but not including week 24 (i.e., a slow
virological response), BOC was discontinued and the
patient received SOC treatment for an additional 20
weeks (2) BOC, PegIFN, and RBV administered for a
xed duration of 44 weeks; and (3) PegIFN alfa

PLEASE IGNORE THE ABOVE- IT'S A MESS as I was trying to compose a clear post. This is what it should have read:

I don't know anything about your circumstances but my understanding is that for noncirrhotic treatment-naive if you:

"remained detectable at any visit from
week 8 up to but not including week 24 (i.e., a slow
virological response), BOC was discontinued and the
patient received SOC treatment for an additional 20
weeks"

which including the lead-in would mean 48 weeks.

This is from the AASLD treatment guidelines. I have it as a pdf so hang on and I'll go find a link...

I told you guys we need a delete/edit button :-)

here's the link:

http://www.aasld.org/practiceguidelines/Pages/NewUpdatedGuidelines.aspx

click on:

"An Update on Treatment of Genotype 1 Chronic Hepatitis C Virus Infection: 2011..." to download pdf. It's on the second page under

'Patients Who Have Never Received Therapy'

My understanding (and I may be wrong as I haven't slept last night) is that your chance of SVR is 66%.

You or someone else should read this to confirm what I'm saying but that I think that was the results for Caucasians in the Sprint-2 trial.

(same source as above)

"The SPRINT-2 trial evaluated BOC in
two cohorts of treatment-nave patients: Caucasian and
black patients.12 The number of patients in the black
cohort was small in comparison to that of the Caucasian
cohort and may have been insufficient to provide
an adequate assessment of true response in this population.
All patients were first treated with PegIFN alfa-
2b and weight-based RBV as lead-in therapy for a
period of 4 weeks, followed by one of three regimens:
(1) BOC, PegIFN, and RBV that was administered for
24 weeks if, at study week 8 (week 4 of triple therapy),
the HCV RNA level became undetectable (as
defined in the package insert as

thanks for your reply...

I do have stage 3-4 cirrhosis and was a previous partial responder in May of 2010..

should know more tomorrow...I'm very hopeful !!!!!!!!

I'm such an idiot - I should've asked first, would've been a lot easier. Good luck and if you look at the pdf you'll probably find the answer...

SVR rates (%) in tx experienced patients:

-----------------lead in - no lead in----------
Pre non responder 41...41
Pre partial responder 59...54
Pre null responder 29...33
Pre relapser 83...88

Artyom to the rescue :-)

**From Incivek**
pi.vrtx.com/files/uspi_telaprevir.pdf
http://www.incivek.com/incivek-resources

2.3 Discontinuation of Dosing

Patients with inadequate viral response are unlikely to achieve SVR, and may develop treatment-emergent resistance substitutions [see Microbiology (12.4)].
Discontinuation of therapy is recommended in all patients with (1) HCV-RNA levels of greater than or equal to 1000 IU/mL at Treatment Week 4 or 12; or
(2) confirmed detectable HCV-RNA levels at Treatment Week 24 (see Table 2).
Table 2: Treatment Futility Rules: All Patients***** ALL PATIENTS**

HCV-RNA Action
Week 4 or Week 12: Greater than 1000 IU/mL Discontinue INCIVEK and peginterferon alfa and ribavirin (INCIVEK treatment complete at 12 weeks)
Week 24: Detectable Discontinue peginterferon alfa and ribavirin


You WILL continue on for sure to week 24, however you MUST be UNDie to go on to 48 weeks.......
You'll be fine,bethann sweetie, just keep on keeping on, and ask for procrit if your HGB is at 9 or lower.......it helps alot.

HANG ON GIRLFRIEND!!!!!! We can do it! Telaprevir warriors we are!

thank you all for the info...

I am currently on victrelis, not incevik....and i have been on procrit and neupogen since week 5...I'll get there !!!!

I have acid reflux right now....so I think I'll go back to bed for a while....

Oops so sorry, I did miss that you clearly wrote that, Bethann and I did know that from our past hugs...

YOU DO DEFINITELY go to 24 weeks. Definitely. There is no doubt as far as Victrelis protocol is concerned.
Stay in the now!

perhaps your red blood cells (HGB) have dropped below 11. This is Anemia.
If so you may receive procrit, and a possible reduction of Riba, as I did. If your WBC counts are below 2, you will get Neupogen.
The shortness is prob Anemia.

Feel better, bed is great. I'm in mine, too.
Hugs and have faith, no worries.

Here

Here is the Algorythym from Victrelis:
http://m.victrelis.com/victrelis/mobile/pdf/AINF-1004659-0002_mobile.pdf

hi bethann, just keep on going! you're doing fantastic! don't stop unless the doctor tells you too. boy, you must be feeling pretty tired. i was put on procrit and neupogen around weeks 4 and 5 too. mucho hugs for you!!!!!!! cheering you on to victory!