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A doctor has come out and stated that millions of people are going to need to be followed due to gadolinium poisoning. Gadolinium Based Contrasting Agents (GBCAs) are used for MRIs and MRAs. The FDA has recently issued a black box warning and all GBCAs are on the list. The two worst products are Omniscan (GE) and Magnevist (Bayer). There is a lawsuit.
Please I ask you to consider your exposure. We need to get the general population to look into their exposure because you will likely be sickened from it. Mine was gradual but you can get the disease soon after exposure as well. I had many injections of this toxic heavy metal but I know people worse off than me that have only had one exposure.
This is an explosive issue and you will be hearing a lot more about this disease as millions have been injected.
Author Interview: Jerrold L. Abraham, MD
Co-Authors: Sanyal S, Marckmann P, Scherer
Multiorgan gadolinium (Gd) deposition and fibrosis in a patient with nephrogenic systemic fibrosis--an autopsy-based review.
Sanyal S, Marckmann P, Scherer S, Abraham JL.
Nephrol Dial Transplant. 2011 Mar 25.
What are the main findings of the study?
The distribution of deposits of insoluble Gadolinium (Gd) phosphates resulting from the release of Gd from the chelated form in MRI contrast agents had not been previously studied at the histologic scale other than in skin. This extensive examination of many tissues from an autopsy case of Nephrogenic Systemic Fibrosis (NSF) documents the widespread distribution of such deposits. Most deposits were seemingly related to blood vessels, but intraparenchymal deposits in cells of some organs such as liver were also noted.
Were any of the findings unexpected?
The most surprising finding was the deposition of Gd within cells in the central nervous system (cerebellum). The deposition of Gd has been shown in abnormal brain tissue (i.e., brain tumors) even with normal renal function, but apparently in some cases of NSF the Gd (either in chelated form and/or after release of free Gd from the chelate) is able to cross the Blood Brain Barrier (BBB) in otherwise normal brain tissue. Although we have detected Gd in myocardium in many other NSF cases, none was detected in this case (most likely a result of solubilization of Gd-phosphate deposits during acidic fixation of the heart).
What should clinicians and patients take away from this study?
The widespread distribution of Gd in tissues of NSF patients highlights the need to prevent this disease and also the need for further studies of the mechanisms involved in the reactions to Gd and the complex problem of calcium and phosphate regulation and sequelae in patients with chronic renal failure (CRF) or end stage renal disease (ESRD). For example, the role of Gd itself in promoting calcium phosphate deposition is in need of further study.
Remember that each single standard dose of Gd contrast agent contains approximately 1.5 GRAMS of the element Gadolinium, of which approximately 1% (15 mg) may be retained in the body (mostly in bones) even in persons with normal renal function.
What recommendations do you have for nephrology health care providers as a result of your study?
First, this study reminds the clinician of systemic involvement by this predominantly dermatologic clinical condition. And the systemic involvement (fibrosis in many organs) is associated with widespread gadolinium deposition. Systemic pathologic involvement when present may be subtle and overlap with findings of chronic renal failure. Since this is a rare and disappearing disease, clinicians should keep NSF in the differential diagnosis of systemic clinical findings in a patient with NSF.
Clinicians should become aware of the potential for release of Gd from various MRI contrast agents (both existing and newer ones) and possible long term consequences of accumulation of a body burden of Gd in millions of patients. This will require long term follow up and investigations by many medical scientists.
Multiorgan gadolinium (Gd) deposition and fibrosis in a patient with nephrogenic systemic fibrosis--an autopsy-based review.
Sanyal S, Marckmann P, Scherer S, Abraham JL.
Nephrol Dial Transplant. 2011 Mar 25.
Department of Pathology, SUNY Upstate Medical University, Syracuse, NY.
Abstract
BACKGROUND:
Nephrogenic systemic fibrosis (NSF) is a systemic disorder of patients with severe renal insufficiency who have received gadolinium (Gd)-based magnetic resonance contrast agents (GBCAs). The causative association with Gd exposure was strengthened by the demonstration of Gd in various tissues of NSF patients, predominantly at the bulk chemical level. The distribution of Gd at the histologic level of organs other than skin has not been reported previously.
METHODS:
We analysed tissues from an autopsy case with verified advanced NSF by light microscopy and scanning electron microscopy/energy-dispersive X-ray spectroscopy. Furthermore, we reviewed published literature to compare the histological and histochemical findings in NSF patients and chronic renal failure (CRF) patients without NSF.
RESULTS:
Insoluble Gd-phosphate deposits were detected in the skin, liver, lungs, intestinal wall (ileum), kidney, lymph node, skeletal muscle, dura mater and cerebellum of the NSF autopsy case, primarily in vascular walls. Some, but not all, Gd deposits were seen in fibrotic areas. Literature review highlighted that non-specific tissue fibrosis and calcification are frequent findings in tissues of patients with CRF with and without NSF.
CONCLUSIONS:
Vascular and extracellular Gd deposits are found in multiple organs of NSF patients, associated with calcification, and often in fibrotic areas. Gd deposits are not seen in patients with CRF unexposed to GBCAs but rarely may be seen in GBCA-exposed patients without clinical signs of NSF. Apart from diagnostic findings in skin, fibrosis of muscle and dura may be more prominent in NSF patients. Our findings should stimulate further investigation of mechanisms of fibrosis and pathologic calcification.
http://www.hemodialysis.com/author_interview_gd_deposition_in_pt_with_nsf.html
Please I ask you to consider your exposure. We need to get the general population to look into their exposure because you will likely be sickened from it. Mine was gradual but you can get the disease soon after exposure as well. I had many injections of this toxic heavy metal but I know people worse off than me that have only had one exposure.
This is an explosive issue and you will be hearing a lot more about this disease as millions have been injected.
Author Interview: Jerrold L. Abraham, MD
Co-Authors: Sanyal S, Marckmann P, Scherer
Multiorgan gadolinium (Gd) deposition and fibrosis in a patient with nephrogenic systemic fibrosis--an autopsy-based review.
Sanyal S, Marckmann P, Scherer S, Abraham JL.
Nephrol Dial Transplant. 2011 Mar 25.
What are the main findings of the study?
The distribution of deposits of insoluble Gadolinium (Gd) phosphates resulting from the release of Gd from the chelated form in MRI contrast agents had not been previously studied at the histologic scale other than in skin. This extensive examination of many tissues from an autopsy case of Nephrogenic Systemic Fibrosis (NSF) documents the widespread distribution of such deposits. Most deposits were seemingly related to blood vessels, but intraparenchymal deposits in cells of some organs such as liver were also noted.
Were any of the findings unexpected?
The most surprising finding was the deposition of Gd within cells in the central nervous system (cerebellum). The deposition of Gd has been shown in abnormal brain tissue (i.e., brain tumors) even with normal renal function, but apparently in some cases of NSF the Gd (either in chelated form and/or after release of free Gd from the chelate) is able to cross the Blood Brain Barrier (BBB) in otherwise normal brain tissue. Although we have detected Gd in myocardium in many other NSF cases, none was detected in this case (most likely a result of solubilization of Gd-phosphate deposits during acidic fixation of the heart).
What should clinicians and patients take away from this study?
The widespread distribution of Gd in tissues of NSF patients highlights the need to prevent this disease and also the need for further studies of the mechanisms involved in the reactions to Gd and the complex problem of calcium and phosphate regulation and sequelae in patients with chronic renal failure (CRF) or end stage renal disease (ESRD). For example, the role of Gd itself in promoting calcium phosphate deposition is in need of further study.
Remember that each single standard dose of Gd contrast agent contains approximately 1.5 GRAMS of the element Gadolinium, of which approximately 1% (15 mg) may be retained in the body (mostly in bones) even in persons with normal renal function.
What recommendations do you have for nephrology health care providers as a result of your study?
First, this study reminds the clinician of systemic involvement by this predominantly dermatologic clinical condition. And the systemic involvement (fibrosis in many organs) is associated with widespread gadolinium deposition. Systemic pathologic involvement when present may be subtle and overlap with findings of chronic renal failure. Since this is a rare and disappearing disease, clinicians should keep NSF in the differential diagnosis of systemic clinical findings in a patient with NSF.
Clinicians should become aware of the potential for release of Gd from various MRI contrast agents (both existing and newer ones) and possible long term consequences of accumulation of a body burden of Gd in millions of patients. This will require long term follow up and investigations by many medical scientists.
Multiorgan gadolinium (Gd) deposition and fibrosis in a patient with nephrogenic systemic fibrosis--an autopsy-based review.
Sanyal S, Marckmann P, Scherer S, Abraham JL.
Nephrol Dial Transplant. 2011 Mar 25.
Department of Pathology, SUNY Upstate Medical University, Syracuse, NY.
Abstract
BACKGROUND:
Nephrogenic systemic fibrosis (NSF) is a systemic disorder of patients with severe renal insufficiency who have received gadolinium (Gd)-based magnetic resonance contrast agents (GBCAs). The causative association with Gd exposure was strengthened by the demonstration of Gd in various tissues of NSF patients, predominantly at the bulk chemical level. The distribution of Gd at the histologic level of organs other than skin has not been reported previously.
METHODS:
We analysed tissues from an autopsy case with verified advanced NSF by light microscopy and scanning electron microscopy/energy-dispersive X-ray spectroscopy. Furthermore, we reviewed published literature to compare the histological and histochemical findings in NSF patients and chronic renal failure (CRF) patients without NSF.
RESULTS:
Insoluble Gd-phosphate deposits were detected in the skin, liver, lungs, intestinal wall (ileum), kidney, lymph node, skeletal muscle, dura mater and cerebellum of the NSF autopsy case, primarily in vascular walls. Some, but not all, Gd deposits were seen in fibrotic areas. Literature review highlighted that non-specific tissue fibrosis and calcification are frequent findings in tissues of patients with CRF with and without NSF.
CONCLUSIONS:
Vascular and extracellular Gd deposits are found in multiple organs of NSF patients, associated with calcification, and often in fibrotic areas. Gd deposits are not seen in patients with CRF unexposed to GBCAs but rarely may be seen in GBCA-exposed patients without clinical signs of NSF. Apart from diagnostic findings in skin, fibrosis of muscle and dura may be more prominent in NSF patients. Our findings should stimulate further investigation of mechanisms of fibrosis and pathologic calcification.
http://www.hemodialysis.com/author_interview_gd_deposition_in_pt_with_nsf.html
leg weakness
muscle pain and stiffness
mental impairment
hair loss
orange peel texture of skin
contractures
fatty liver
muscle pain after exercise
burning in hands, legs, arms and feet
I give up...I had an MRI 4 years ago :(
I am going to work with a doctor. At least I finally know why I'm sick. It took me nine years but I know the why and perhaps it will lead to health.
Did you have contrast with your MRI. Usually if it was for soft tissue they would give you the contrast. It only takes one dose if you were dehydrated when they gave it to you or after. I'm not trying to make you worry but if you had contrast you are likely sick from it.
They definitely used contrast but I don't know what kind.
Should I be worried? What should I do? I'm about to lose my health insurance in about a month, I'm not going to be able to afford to pay for testing and all of this. I may have Elhers-Danlos and once I see the geneticist I will know for sure if I have that and then my money and resources will be spent on that.
This news of the contrast poisoning first came out in 2008, and I think they stopped using these contrasts at that time, but I'm not positive of that. Research....research....research. I looked under MRI contrast poisoning and mostly got articles from lawyers wanting clients....go figure!
These gadolinium based contrasting agents are still on the market and still being injected into the unsuspecting victims. It is going to cause massive amounts of additional healthcare costs in our country and around the world and yet the FDA goes after benign products that do no harm and may even help like light therapy and beet juice extract while this toxic-heavy-metal continues to be injected in babies even. It's a crime I tell you.
My sister was very sick with the dye, from heart tests.....
DEF> need to do natural chelation before doing those tests....and yes Gs, I am with you! There is ALWAYS hope for healing!!!!
I had a dyed based cat scan of the brain during testing for FM by my rhuemy doc. Not sure what type of dye was use ?
Have had several MRI's but don't think dye was used for any of them ?
Have had SI injections for treatments which are guided procedures for my low back and guided injection procedures on my neck not sure if dye is used during those procedures or just cameras ?
Can I ask how they tested and found out this was a problem for you ?
Have they said or mentioned any way of removing these metals from your system ?
Take care
gentle hugs
I only have the 1 Kidney...so this gets to be a bit scary for me..but what to do ?
As to how I found out. I had had a biopsy from a long time ago and had the tissue sent to a lab to be tested and it had gadolinium in it.
At this time I would do more research and find out more facts. If you think you are impacted email me and I will give you some things you can do to get a diagnosis. Take care.