You might need to take Abilify on top of it and also may need to up your dose on Lamictal.

i started off on 25mg each day for two weeks, 50mg a day for another two weeks, then 100 for another 2 weeks, then some time after that i went up to 200mg a day. im now on 300 mg and its working well. i need high doses as i have BPD and my mood swings all over the place. maybe ask for a higher dose. it didnt really work for me till it got to atleast 200mg a day.
good luck.

I agree that you may need a higher dose. I take 200 mg. daily after gradually increasing it over time.

Thanks for the replies everyone. I didn't realize the dosing was that high. At this rate I'll never get to the therapeutic level and feel better. I was on Zoloft but it stopped working for me. I also take an anti-psychotic with mood stabilizing qualities called Saphris. As far as I know I just have major clinical depression that appears to be treatment resistant to just about everything I've tried so far.

I've heard you can use lamictal for depression but I personally use it to treat Epilepsy and have done so for a few years. I also have depression and I can say it's done nothing to help that (seizure-free for about two months though!). Maybe you might want to consider talking to your doctor about changing medication.

I saw her on Thurs. We upped the dose and will keep upping it until I reach 100mg. Then wait and see if any rx/ change in mood. Also upped my Wellbutrin to 300mg. So hopefully in about a month I'll be feeling better. I just need to hold out a few more weeks. I've only been on Lamictal for about 1.5 months so I'm willing to wait a few more to give it a real go and see if it works. My pharmacist says she's seen it really turn people around, her son included and she thought it was one of the best drugs out there.

I didn't notice much help until 150 or 200mg. 100 minimum would be where I think you would notice it help. One time it really pulled my ass out the fire. and I was on 150mg
Good luck

I'm now up to 150 mg of lamictal and 300 wellbutrin and my bf says he sees a difference. I guess that's the 1st sign, that others notice it before you do. I'm crying less or not at all most days. I do feel like I can now smile and laugh at things whereas before I was unable to enjoy anything. My sex life is much better too than when when when I was on zoloft.

I am not sure what magic number of therapeutic range for it but I am on 200 mg once a night. Check with the pharmacist or your doc but I am on an anti-depressant along with it. So each person may be on a different dose depending on what other meds they are on. Tell the doc and ask them if you can take something else or up the dose. You be in charge of your meds too by making suggestions and trying other meds along with it.

It took 6 months for the Lamictal to take me from severely depressed to a normal mood where I could be happy. My psych MD says it is slow to build up in your system but works great once you are there. It has to be titrated up slowly because you get a deadly sick condition.

I take 400 MG of the generic. Sometimes you need a higher dose if you are taking the generic. Are you taking this with a low dose antidepressant as well? I take 30mg of Cymbalta. Usually you need antidepressant too but lower dose than if you werent taking Lamictal.

Hope this helps give you some hope. I wouldnt give up on it yet. I know how terribly painful the waiting can be. Hopefully someday they will have drugs or treatments that work faster.

BTW, I liken the phrase treatment resistant to "meds are crap" . It just sounds better and it looks better for big Pharma to say it's your fault and not theirs. After my near death experience with meds I did a buttload of research on psychotropic meds and let's put it this way...if it wasn't for the placebo effect and biased self reviewed clinical trials that are often bogus, no one would be on meds.
True some people get help on them but at what price? Your hair falls out, your liver fails or you develop dementia or tardive dyskinesia?
Personally, if I could use I time machine I would go back in time and never have taken a med in the last seven years, I'd still be okay today instead of trying to find effective methods to off myself.
Look into a supplement called SAMe, it makes pharma drugs look like the joke they are. Check out even reviews on here...very highly rated and in Europe it's prozac to some of them.

Make sure it doesn't clash with your meds though and I mean make sure, check online and with the pharmacy don't trust your Dr on this...they are almost clueless when it comes to interactions.

Lots of people have a problem with methylation and none of this serotonin shortage bunk...that's a broken theory designed to sell more drugs. Trust me on this....there are no meds tested beyond six months do if you are on them any longer than that you might be putting your health at risk. And I've read enough to know what I'm talking about here but I'm also not saying to just stop meds either. It's just the aren't nearly as safe or innocent as a drug company says. ...ever.

Oh, another thing. GSK makes Lamictal and they were just fined 3 billion dollars for lying and witholding negative clinical results...they are one of the most corrupt companies on the face of this earth. Please consider this when you feel feverish, flu like symptoms, hair loss or sudden deafness, never mind Steven Johnson syndrome. Again, not trying to scare anyone because this can be an effective drug for many many people but it's not like taking vitamin c or anything like that.
Still, have seen some miraculous results with it nontheless so it definitely works like magic for the ones that benefit. I still think the CEO for GSK should be publicly hung though.
Peace

I also started on 25mg and increased gradually up to 200mg. I was told as well that it would start kicking in and having effects as soon as I reached the top dose of 200mg a day.

Now I must say I also take Luvox (Fluvoxamine) and Risperidone for anxiety, obsessive thoughts, etc.