I don't think there is a Cure as you ask or as anyone could really come up with to talk about. I think there are things that really help depression.

I have suffered on and off for many years with depression. I am currently stable on medication and in a healthy relationship so my depression is must less then normal for me for the past several years. I take Effexor CR and Abilify and for me that works really well after years of trying many( almost everything) medications on the market. I also attend bi-weekly therapy and that always helps me to have a non-biased person to talk to about my issues.

I have been through a lot in my life. Just a few things I have faced and beat are molestation, child death, abusive parents, abusive spouse, divorce, death of only brother, death of parents. Like I said these are just a few things I have been through and I am still going. Depression is like any other disease and it can be control to a certain extent, but the person suffering from it has to take it upon themselves to want to get better and not let the self loathing, and low self esteem take over them.

I wish you the best of luck and I am usually around during the week if you want to talk more about this.

There isn't a tried and true cure for depression. That doesn't mean there is nothing that helps, but what helps one person can be totally different than what helps another. I'm still looking for what helps me, but others have found relief in medication and/or therapy.

The best treatment starts with a proper evaluation. Once you get to the root of your issues (and this could be brain chemistry, it could be traumatic experiences, it could be many things) then it is time to attack them.

If the root cause is some sort of brain chemical inbalance then meds are likely going to be a required life long treatment.

If the root cause is a traumatic experience then dealing with that is the issue. If you can overcome the experience then you will be "cured". If you can't overcome the experience then you will need to focus on controlling the things that trigger memories of the experience.

Sorry to be so vague.

There is cure for it. Depression caused by disbalance of chemicals in brain. There is such chemical as dopamine. Problem is whether you have high or low dopamine it causes depression any way. They have test that they can use to determine whether your dopamine is low or high but as doctor said it is not comonly done. Doctors prefer give patients meds randomly without test because they can money anywayand pharmaceutical companies make more money if more meds sold. There are psychiatric meds that increase dopamine and psychiatric meds that decrease dopamine. In order to get rid of depresion dopamine should reach middle level normal for human. If test would be done and level of dopamine would be determined than it is easy to fix by giving correct medication that increases or reduces it. Obviously since test usually is not done medications are given randomly and person suffering may never reach normal dopamine level. It can be too high or too low depanding on what medication you are taking and what amounts of it you are taking. It is hard blindly randomly hit target and that is what psychiatric professionals usually do prescribing meds without testing dopamine level in patients. Somehow when doctors treat diabetis they check sugar level but in psychiatric care they generaly do not test level of dopamine before prescribe meds.

I have had it for going on 30 years, I have tried every medicine available. Most work for awhile, then stop. It is not the same for everyone. Some people react better to medications than others. I will tell you one thing, with my depression, anxiety comes. The anxiety makes the depression worse & makes me sick to my stomach. I recently had a bout with high blood pressure & the blood pressure medicine has helped my anxiety more than anything. I have never had HBP before in my life, but Ive never been under such personal stress. Come to find out, my PMR is recurring & that is what raised my BP, and I started steroid treatment again. I am still going to take the HBP medicine because it helps & my psychiatrist is ok with it. Just keep trying different medications, you may find one that works well for you. lostsoul is right, if you are in a healthy relationship, that helps. I am not in a healthy marriage, which compounds the depression/anxiety. Good luck.

p.s. lostsoul, I thought I lived in shit hole NE, lol. Maybe there is more than one in NE.