I've only been on it for 5 weeks. Your mileage WILL vary.

My pulmonologist prescribed it because MY disease had progressed to where the warning signs of flare-ups (mucus blocks) were less recognizable - therefore essentially having more because they would come on sudden and surprise me. He suggested that Daliresp would 'even' things out. So far he has been correct - it has helped.

Unfortunately he was also correct about the side effects. He said the most common complaint was its effect on the GI tract. I was to only try it for a month and see if I could "tolerate it" (his words - a definite warning. smile).

The very next day of trying it - I immediately got the runs. Pretty bad. Since then I've gotten more stable, but still always feeling slightly bloated, but I've NOT had a single surprise flare-up and have a steady flow of stuff to clear - both ends. Smile
So I've opted to stay on it.

Later stages of COPD tends to be a balancing act.

I have severe COPD and have been on Daliresp for over 1 yr. I am taking so many meds that I am sometimes unaware of what is causing what. I was taking 2 inhalations twice daily. My dry cough seemed to get worse so I dropped back to 1 breath once daily and seems better. I too have had some stomach problems, but I have some side effects with most of my meds.

I was on Daliresp for a couple years. I found the side effects to outweigh the benefits of the drug. I still had the same amount of flareups and I found it also lead to dark suicidal thoughts that I
hadn't had before or since.

Kiddo, I have been using Daliresp for almost 2 years. My Doc prescribes to me as part of a preventative maintenance plan. This drug in conjunction with all the other stuff I take seems to work together. On of the best things I found about Daliresp, is that during the 1st few weeks you lose some weight, and as your body adjusts to the new drug the weight lost stops. It is quite expensive still, and I only use it because my Doctor provides me samples. I know this wasn't help, but I hope it was some. Take care, Bill

I have taken it for about 2 years and have had no problems with it. I did loose about 20lbs., which for me was a good thing. It has worked very well for me, I have not had as many hospitalizations , only one brief illness since I have been on it. Before that it was a 1-2 a year.

Thanks all for your responses. We are going to start the drug tomorrow. I will let you know if it helps.

After one week on the drug we had to stop - he has anxiety at times and his anxiety attacks tripled on this medication. He was in really bad shape. I stopped the Dalisrep and the anxiety attacks stopped. They say anxiety is a side effect and I guess the drug just made it worse for him. The good news is that the medication did bring him a ton of relief from the mucus/phlegm and not give him the runs, but he also started having nausea and lack of appetite. Was worth a shot!!!

sorry it didn't work out for him. did the fluconazole and antibiotics give him any releif?

The antibiotics and the Medrol (prednisone taper) did help a lot.....but as usual, once those are done, the coughing, etc., come back. The fluconazole will probably be long term. The doctor said it will be an up and down battle from here on out. :(

I added another two weeks since I last posted, thus more adventures.
I developed insomnia, the real thing, which was a first for me. Ive had occasions where I couldnt sleep because perhaps too much caffeine, too much excitement, restless leg, etc., but this was very different. Super tired, muscles tired, eyes tired, calm, body screaming for sleep, but when I closed my eyes nothing.

Changed dosage to very early in the morning - no go. Doctor suggested I cut in half. (Lots of fun there the pill is dinky to start with.) That seems to be working as I can finally sleep but never more than four hours at a time.
Losing several pounds a week (12 pounds so far), which is OK, but apparently from the wrong places - still have my doughnut. Easily explained have absolutely no appetite. Find myself suddenly realizing I havent eaten at thing all day. GI still cycles regardless of diet.

However, Daliresp does its job. Ive had no flare-ups, no coughing attacks, and no stuck mucus. That is, zero exacerbations. Seem to breath better, can walk a tad farther, and last a wee bit longer at tasks -when I get some sleep. Unfortunately, at this point, Im not sure how much of this kind of healthiness I can stand. LOL

Not surprised to learn your husband quit. I would have bailed myself, but Im trying to help out the doctor. There is always the possibility I might become more tolerant. Ive been lucky up till now. Ive had no serious side-effects or reactions to any of my many meds. Guess it was finally my turn. LOL