Sounds like a possibility...the supplements are easy to get. Might try a round and see if it helps -couldn't hurt. (Easier than convincing the doctor and paying for blood work)

Very interesting read. I might have to change my diet.

Thanks for the information. It looks like it's helpful. At the very least maybe some more light at the end of the tunnel.

I just have to say this! I read this article. All of it. It makes PERFECT sense to me. I've ALWAYS believed that mitochondrial dysfunction is what keeps us down. ALWAYS.l

If you read the article, you will hear about Dr. Steven T. Sinatra. He has a book out on this subject. I googled him. He is a board certified cardiologist and his articles hit home with me in such a huge way that I teared up!

Please read this PDF. Think about it. We all came to this illness in a different way, but isn't it most probable that the reason we all end up with total body dysfunction and exhaustion is because our energy system is broken? It doesn't matter HOW we got here, what matters is what can we do to get our Mitochondria working.

Oh my gosh.

Thanks for this post, Ruby. I know a lot about Dr. Myhill! She is also working on the documentary "Canary in a Coal Mine" with Jennifer Brea. This is a doctor who really knows her CFS stuff.

Oh my gosh!

Bummer. I already take all of those supplements (2x/day) except L-carnitine. Can't hurt to throw it in there and see what happens.

I have always agreed that it's a mitochondrial issue at the core, and my blood pressure AND volume have both been charted as low. It all makes sense.

My blood pressure is normal. I'm wondering how many of us have low BP.

But I have noticed that I feel better when I eat red meat and when I became ill, I eliminated red meat from my diet almost entirely. Hmmmm.....

Yes, I've had a doctor explain mitochondrial dysfunction to me since he believed that's part of the fibro/cfs dilemma. He recommended acetyl-l-carnitine and D-ribose and several other supplements, too. I recently purchased a different brand of acetyl-l-carnitine (Country Life), and this one seems more potent than the other brand I was using. I've increased the dosage using Dr. Myhill's recommendation, and I feel better. Helping with brain fog for sure. Also increased my COQ10 dosage as well. I've tried D-ribose before and it did increase energy, but it flares up my candida issue, so I had to stop.

It's interesting about the doctor's recommendation for red meat. For 20+ years I did not eat red meat at all and was mostly vegetarian at one point also. Now I practically crave red meat so I make sure to buy some every week. I buy mostly grass fed beef and beef raised without antibiotics/hormones. It does help my energy levels for sure.

Thanks for the link, Ruby, I had read parts of it some time ago but needed the refresher!

It is interesting ... I'll have to talk to my doctor and see if he knows about this. My blood pressure and pulse rate are always low.

This makes allot of sense. I always have low blood pressure. I truly believe our energy source is broken.

Wow! Except for the low blood pressure this is me to a T. Palps and high blood pressure are my heart problems. I have craved sweets for the past year more than normal and put on 20 lbs. I was feeling better and may have over done it for about 6 months but now I feel like I did when I first
had the symptoms of CFS. This sounds like the answers to most my problems and I have never taken sups yet. Now what? Try it and wait to see what happens? I have heard of lots of us taking many sups with not much benefits, so I hesitate to start now. This does seem to be possibly true but again, What now?

I take the Ribose, COQ10, and Acetyl-L-Carnitine, but not at the high doses recommended. Perhaps that is the key. I guess it's worth trying to increase and also add the magnesium and niacin. I also feel better when I eat red meat. I discovered by accident one time that if I eat red meat the 3 days before my period starts I have almost no change in symptoms.

Thank you for sharing. Her theory on mitochondrial dysfunction and her supplement recommendations line up with what my medical team believes. I've tried all of the supplements she listed and got mixed results. Unfortunately I had to stop them because of my multiple GI issues. I'm super sensitive. Magnesium is one that I still take. Hoping I will be able to try the others again!
What worked best for me when I was trying them is to try one at a time and under a drs supervision. Not just for safety reasons but also because they can help you "tweak" dosages, monitor side effects, etc. if needed.