My advice is to give your meds time to work. I think it takes a couple of weeks to notice a change in mood and behavior. As for not sleeping, have you tried melatonin? I used trazodone for quite a while to help me sleep and it is an antidepressant as well. I hate to push more meds at you but I’m just sharing what helped me. Not to say it will help you but it may

hi TC40, I would maybe ask your Doctor if you should be taking your meds at a different time than you are now. Also, just what I try to do is keep on a really constant schedule with my meds....take them nearly at the same time every night.

One other idea is that I take half a tablet of Trazedone with my nightly meds - and that is supposed to help with sleep. I don't have sleep issues - so I guess it's helpful... I also try and sleep the same schedule every night when that's possible -so it makes falling to sleep a habit and not a big adjustment. Just thoughts.

Have a good Doc visit. Peace and best, Mark

by a different time I mean - like maybe you should take it in the morning versus night. So that the ramped up feeling will not effect you at night.

TC40. Sorry to hear this. I was on Ambilify and Lexapro for a while and for me it did not nothing. I guess different brains are different. Maybe ask your doctor about your issues.

I did take it in the morning. I take benedryl, melatonin and remeron at night. I’m still taking the lithium until Tuesday.

Hang in there tc. Try as best you can to keep trying for a solution with your pdoc so you can sleep. It’s no fun changing meds so I wish you mucho relief very very soon. Turn off electronics and try reading a really boring book!

I am sorry you have to go through meds change. I switched from lithium carbonate to sodium valproate recently and experienced some undesirable mood changes. I did not sleep well initially for a few nights, but then got used to the change shortly after that. Thank God. Hope you will be able to find the right meds for yourself.

TC with all the med changes you've went through in the recent weeks, it's going to take some time for your body to adjust.

These meds just don't work that quick, and your starting new ones, while stopping current ones....unfortunately its going to take time for your body to get detoxed and leveled out.

Even if your not sleeping, try to lay down and rest. If you feel too antsy to lie in bed, do things like take a hot bath to relax, spray lavender essence on your bed sheets and pillow, have a hot chamomile tea before bed, keep your bedroom very cool at night, put on relaxing meditative or classical music at night softly. Do what you can to help your body/brain rest and hopefully as the chemicals balance out you'll move from resting to sleeping.