Atrial Fibrillation (AFib) Support Group
Atrial fibrillation (AF or afib) is an abnormal heart rhythm (cardiac arrhythmia) which involves the two small, upper heart chambers (the atria). Heart beats in a normal heart begin after electricity generated in the atria by the sinoatrial node spread through the heart and cause contraction of the heart muscle and pumping of blood.
If you have healthy kidneys, and no history of GI problems, ulcers, etc. and especially if you have difficulty with keeping your INR in range it is an alternative.
The Advantages of Dabigatran
Dabigatran is a pill taken twice daily as a fixed dose. It is immediately effective, versus the slow, several day onset for warfarin. No monitoring is required: no blood tests. It doesnt interact with foods. It only interacts with a few drugs that affect levels of P-glycoprotein (such as rifampin, verapamil, and ketoconazole). Randomized controlled trials (RCTs) have shown that it is more effective than warfarin in reducing strokes and embolism and that it is less likely than warfarin to cause major bleeding complications. The difference is relatively small: the number of patients who would need to be treated (NNT) with dabigatran (rather than warfarin) to prevent one hemorrhagic stroke is approximately 370.
The Disadvantages of Dabigatran
It must be taken twice a day instead of once. Consistent timing of doses is important, because its effects wear off quickly compared to warfarin (its half-life is 12-17 hours vs. 20-60 hours for warfarin). It is more likely to cause dyspepsia (indigestion) and gastritis, and has a higher rate of major gastrointestinal bleeding (1.51% compared to 1.02% for warfarin). It costs about ten times as much as warfarin, around $200 a month.