Anxiety Support Group

Anxiety is a physical condition marked by intense and persistent feelings of distress, fear, angst or dread. General anxiety caused by routine day-to-day stresses usually passes quickly and is experienced by almost everyone at one time or another. However, such feelings that linger over time and are very difficult to cope with, and which lack a clear cause, may indicate...

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SSRI no longer working?

OhCarol
OhCarol

Has anyone ever had this happen? If so, was there a solution? I've been on 20mg paroxetine for 17 years.  I've been feeling worse for the past 8, almost 9 weeks. When I called a free 24/7 nurse hotline free with my health insurance, the nurse suggested that I may have developed a tolerance for it. I hope to get an answer this Friday. Honestly, I hope there is an answer.

GirlinCalif
GirlinCalif
I've been on the same SSRI for over 25 years. I take it once a day. Mine feels the same every day of the 25 years. I take the same dose every day.

I have not heard of them stopping working in one day. As long as you are taking them every day, the same dose each day, not skipping any days, or taking it at a way different time... then I would assume they are working.

I am thinking something is up with changing your doses around lately. That can make it feel "different".

Hmmm, just thought of something actually.... you take generic, right? Did you happen to fill your prescription with a different looking generic this last time? All generics are different, and act different. That might be your problem right there.

It's hard, but try not to think about it or look for symptoms. The more we look, the more our mind plays tricks on us. Try your best to just do your usual daily routine. Friday will be here soon. I so hope they will have answers for you. Let us know.
Tired
Tired
Yes my Paxil stopped working after a number of years. My psychiatrist changed me to Prozac. Had to taper down first drug then slowly build up new drug in my system. New drug works fine.
Community LeaderMid
Mid
There are many factors to consider when checking out changes to medication.

First, hydration sensitivity can happen, overwhelming anxiety in stressful situations, and lifestyle changes.

Take a breath, stop, pause, and repeat until calm. Repeat as needed.
mtd
mtd
It could also be that your anxiety symptoms has worsened beyond what the meds can control.
abrokenmom
abrokenmom
I'm guessing that your symptoms have gotten worse, I kind of went through the same thing. I know my anxiety is way worse this past year than it's ever been. SSRIs can stop working, though.
jannytheresa
jannytheresa
It's very common for anti-depressants to stop working. Some call it "poop out"
For some people tapering off the anti depressant and then reintroducing it can work but doctor's will want you to try something new.

Good luck
GirlinCalif
GirlinCalif
I think also skipping some days of taking it, as your doctor suggested (not sure why they would suggest this though) will cause you to feel "off" for the next couple of days.
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