I wont ever touch another psyche drug but I have a good friend who is on Zoloft and over the past 5 years has gone up to 250 mg and is worse now that when he was on nothing

He is trying to taper but he cant work and taper so he is stuck

I was on 25 mg for one month, then went off for a few weeks, had a major panic attack, major anxiety attack, and am on 50 mg in the morning. I have to take it with a full glass of water to prevent the side effects of dry mouth, throat sticking sensation, and keep hydrated during the day as mild dehydration is the only warning I have of the changing chemical levels.
It works to keep my panic/anxiety/depression from going from 0-150 in two seconds flat = roaring tornado flapping arms, screeching voice, and other not so funny physical symptoms.
However, I am in cognitive behavior therapy treatment to help me with these sensations, even though they are often not visible to others, they describe what I feel inside, and affect my ability to maintain normal daily living activities.
For those people who have had their dosage increased, the scary side effect of zoloft withdrawal is often multiple reactions coming together in one form, and it's hard to figure out how to stand strong and firm through the sensations.
One thing that does help me is when I have to change the time I take the medicine is to do physical activities, and keep my toes moving. That prevents the chemical change from overwhelming a specific sensation, and I feel better even with the anxiety.
Hope this helps.

I started at 12.5 mg and never went any higher. Somehow that seemed to really help bc while I was on it for 7 months I felt great. Obviously stopping was easy with no side effects/withdrawal at all.

My husband was on it too (he is also off now) he started at 25 for a week then 50 for a week maybe two then up to 100mg. He had bad GI side effects at that dose so he opted to stop taking it.

When I was taking it I was on 200 mg. a day.

At one point I was up to 200 mg a day but I am now down to 25 mg a day. I have been taking zoloft for about 13 - 14 years.