I was always told to take you meds at your usual time don't change if possible. But don't take too close to new bedtime as you won't sleep. if your gone for long time you can adjust slowly to new time in small time increments day 30 mins or more if you think you can handle that. Travel is stressful enough. Even when it's for fun.

try taking extra during times you would normally be asleep. Have a safe trip! Best wishes to you!

It may have been just the stress of traveling? I know I usually have to fly with my two little ones, and that is stressful, so I take a bit extra cortisol, and it helps. I don't think it has anything to do with the time difference?

I've flown several times from east coast to west coast and to europe with AD. I pretty much gauge my steroid doses based on the amount of time it takes for me to metabolize the current dose. Normally it just means offsetting my afternoon dose by a couple of hours or adding an extra 2.5-5mg at a later time to ensure I have enough energy to get me through until bed time. I also make sure I travel with my emergency injection, just in case of an emergency during a long flight.

Oh, and as for medication schedule. You need to adjust your hydrocortisone according to your schedule needs. It metabolizes in 8-12 hours, so it doesn't make sense to take your dose at 2pm if you're planning to stay out until midnight. You might find yourself running out of steam by 10pm! Besides, you're body's needs will vary depending on what's going on in your life and any infections, mild or severe, that it's fighting. Not taking too much close to bed time is good advice because it can affect your sleep, but you need to find a reasonable balance for your medication schedule and dosing so you don't over-medicate but still have enough energy to keep up with life.