Has anyone here taken Picamilon or Phenibut? Picamilon is able to cross the blood-brain barrier and hydrolyze into GABA. Phenibut is a derivative of the naturally occurring neurotransmitter GABA. (The addition of a phenyl ring allows phenibut to cross the blood brain barrier).

If I may restate what I have discovered for myself only; I firstly get a full 8 hours of sleep (very important), and when I wake at 4am hit my brain with a huge boost of some neurotransmitter(s), let's call them "GABA" for now, which stops the excitation of noise in my brain eliminating my tinnitus for the rest of the day. Let me repeat; my loud tinnitus is totally eliminated for the rest of the day. Also, the ringing in my ear never returns during the next 14-16 hours while I'm awake that day (making sure not to fall asleep during that period).

I understand how a singular boost in "GABA" could eliminate tinnitus for a while but why would it continue to suppress all idiopathic tinnitus noise during the rest of the day? I'll emphasize the noise is truly gone, not just ignored nor habituated.

The following is a highly scientific explanation of what is occurring in the brain when alcohol disrupts neural activity. I post this for analysis to explain what may be happening to me. "The main effect of "GABA" is to reduce neural activity by allowing chloride ions to enter the post-synaptic neuron. These ions have a negative electrical charge, which helps to make the neuron less excitable. This physiological effect is amplified when alcohol binds to the "GABA" receptor, probably because it enables the ion channel to stay open longer and thus let more negatively charged chloride ions into the cell. The neurons activity is thus further diminished, explaining the sedative effect of alcohol. This effect is accentuated because alcohol also reduces glutamates excitatory effect on NMDA receptors."

Given my over 1500 successful trials so far, I propose a simplified theory for most tinnitus sufferers, that a significant lack of "GABA" causes increased neural activity by preventing chloride ions to enter the post-synaptic neurons which causes tinnitus as the neurons fire out of control, creating a sense of loud noise when there is none being received from the cochlea. Most of us are essentially suffering from a significant lack of "GABA". This is why I am trying to find methods (including but not limited to psychological therapy) that will restore these levels back to normal. This may include supplements that are able to pass through the blood-brain barrier.

I would appreciate feedback from anyone who has tried Picamilon or Phenibut. -Rudy

Rob x 2 #132 [-]
Posts: 4025
(11/15/11 9:16 AM)
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My Recent Posts Initial studies on the effect of gabapentin on tinnitus by Bauer and Brozoski (2006) suggested a positive impact in animals and some human subjects; however, a more recent clinical trial regarding the relief of idiopathic subjective tinnitus by Piccirillo et al (2007) and a pilot study by Witsell et al (2007) showed no difference when gabapentin was compared with placebo. If gabapentin has a positive impact on tinnitus, it may be that only a small number of patients experience it.

Agents that activate the inhibitory receptors for GABA-A (benzodiazepine) and GABA-B (baclofen) were shown to suppress tinnitus-related activity in rats in a study by Szczepaniak and Moller (1995) and in hamsters in a study by Zhang and Kaltenbach (2000). However, studies with these agents in clinical trials have shown mixed results. Baclofen was shown to have no impact on tinnitus in a double-blind placebo controlled trial by Westerberg et al (1996). In a study by Bahmad et al (2006) on the use of benzos to treat severe disabling tinnitus of mostly cochlear origin, and a study by Gananca et al (2002), many patients improved with respect to reducing the severity of their emotional reaction to tinnitus and a subgroup of those patients experienced a decrease in tinnitus loudness