Here is and interesting post, on somebody who has taken Picamilon.

Has anyone here taken Picamilon or Phenibut? Picamilon is able to cross the blood-brain barrier and hydrolyze into GABA. Phenibut is a derivative of the naturally occurring neurotransmitter GABA. (The addition of a phenyl ring allows phenibut to cross the blood brain barrier).

If I may restate what I have discovered for myself only; I firstly get a full 8 hours of sleep (very important), and when I wake at 4am hit my brain with a huge boost of some neurotransmitter(s), let's call them "GABA" for now, which stops the excitation of noise in my brain eliminating my tinnitus for the rest of the day. Let me repeat; my loud tinnitus is totally eliminated for the rest of the day. Also, the ringing in my ear never returns during the next 14-16 hours while I'm awake that day (making sure not to fall asleep during that period).

I understand how a singular boost in "GABA" could eliminate tinnitus for a while but why would it continue to suppress all idiopathic tinnitus noise during the rest of the day? I'll emphasize the noise is truly gone, not just ignored nor habituated.

The following is a highly scientific explanation of what is occurring in the brain when alcohol disrupts neural activity. I post this for analysis to explain what may be happening to me. "The main effect of "GABA" is to reduce neural activity by allowing chloride ions to enter the post-synaptic neuron. These ions have a negative electrical charge, which helps to make the neuron less excitable. This physiological effect is amplified when alcohol binds to the "GABA" receptor, probably because it enables the ion channel to stay open longer and thus let more negatively charged chloride ions into the cell. The neurons activity is thus further diminished, explaining the sedative effect of alcohol. This effect is accentuated because alcohol also reduces glutamates excitatory effect on NMDA receptors."

Given my over 1500 successful trials so far, I propose a simplified theory for most tinnitus sufferers, that a significant lack of "GABA" causes increased neural activity by preventing chloride ions to enter the post-synaptic neurons which causes tinnitus as the neurons fire out of control, creating a sense of loud noise when there is none being received from the cochlea. Most of us are essentially suffering from a significant lack of "GABA". This is why I am trying to find methods (including but not limited to psychological therapy) that will restore these levels back to normal. This may include supplements that are able to pass through the blood-brain barrier.

I would appreciate feedback from anyone who has tried Picamilon or Phenibut. -Rudy

Rob x 2

Never heard of Picamilon or Phenibut? What is it and where did you buy it? Just curious.

I see that Picamilon is niacin combined with GABA. I checked a good online source to check ototoxicity and this is what I found:


Can Niacin (Vitamin B3) Cure Tinnitus?
by Neil Bauman, Ph.D.
(www.hearinglosshelp.com) and author of Ototoxic Drugs Exposed

A man wrote:

Several years ago at a hearing clinic, I told the young lady that I had ringing in my ears. She asked me if I had ever taken Niacin, and I hadnt. She said it helps some people. I took Niacin pills for a good while, and it seemed to rid me of the ringing in the ears. I did get a flushing from taking Niacin. She suggested Niacinamide, and that seemed to help the flushing.

For one reason or another, I have not had ringing in my ears for a lot of years, so I no longer take Niacin or Niacinamide.

I would like your thoughts about taking Niacin or Niacinamide for ringing in the ears. Do you know of a connection here, or was it helping me a fluke?

Niacin (Niacinamide) or Vitamin B3 helps some people with tinnitus because it increases blood flow to the peripherals which includes the inner ears (hence the flushingit shows it is doing its job).

If your tinnitus was caused by a lack of blood to your inner ears, then taking Niacin really can workits not a fluke. However, Niacin does not work for everyoneonly for those with circulation problems to their inner ears. For example, nothing Ive tried has helped my tinnitus because mine is probably the result of my severe hearing loss, not lack of blood flow to my inner ears.

Dr. Neil Says:
October 30th, 2009 at 7:32 am
I could only find 2 anecdotal reports of people whose tinnitus got worse from taking niacin. So it does appear that in some people taking niacin can increase their tinnitus. Thats the bad news.

The good news is that it seems in both cases when they stopped the niacin, their tinnitus went back to its usual level. Thus the increased tinnitus is temporary.

Therefore, if you try niacin and your tinnitus gets worse, just stop it and your tinnitus should return to its old level in a few hours or days. However, I think the vast majority of people that take niacin do not have any increase in their tinnitus, and for some it does reduce their tinnitus.

Neil


Phenubit is a derivative of the naturally occurring inhibitory neurotransmitter -aminobutyric acid (GABA).
The addition of a phenyl ring allows phenibut to cross the blood brain barrier.[1] Phenibut is sold as a dietary supplement in the United States, while in Russia it is sold as a neuropsychotropic drug. It has been reported by some to possess nootropic actions for its ability to improve neurological functions,[2] however other researchers had not previously observed these effects.[3] However, it is generally accepted that phenibut has anxiolytic effects in both animal models and in humans.[1] Phenibut was discovered in the Soviet Union in the 1960s, and has since been used there to treat a wide range of ailments including post-traumatic stress disorder, anxiety, and insomnia.[2]

The name phenibut, along with many of the other names for the compound, comes directly from the chemical name for the compound, -phenyl--aminobutyric acid.

I was unable to find any information on whether Phenibut is ototoxic to your ears.

Judy

Thanks Judy, I am feeling pretty good about this.

Also, it helps me sleep at night.

I am excited !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Do you get this at the health food store?
Sue

This is very good news! To help yourself you need to research and then research more. Don't wait for a doctor to tell you what to try. This IS good news!

No Sue, you don't have to drive long distance to buy Picamilon.

Stores don't carry it. Buy it online..

Amazon had the best pricing, $12.00 for 120 50 mg pills.

Picamilon was made and pattoned by the Russians.

In Russia it's by perscription only, in the United States, it sold as a supplement, no persciption.

I am interested in this but being produced, patented and mail order only out of Russia. I question it's safe use here in the U.S. From all that I read, sounds promising. Think I might try Niacin first though I think mine may be more of a GABA thing than a blood flow thing. I am just scared to take anything as to not make my situation worse. Hearing or vision. omg.

Is the Rob 2 from the yuku site?

You can buy the non-flushing Niacin over the counter. Regular niacin will make you flush a lot. Dont know if it's by Nature Made or not. Nature Made has a USP seal (U.S. Pharmaceuticals) verified for potency and pureness. Did some research on the USP label, never see it on other brands. Best of luck to anyone who tries these things and let us know how you do.

Yeah, Rob x 2 is from Yuku and he might have quoted that post to argue with it because I really doubt he wrote it.

Anyway, Amazon has some for $20. Might give it a go.

so has anyone on here tried Niacin and have it help?

My very first time I saw an ENT he prescribed it. He told me you can buy it otc. Went to Walmart and bought some. I think it was 500mg in strength. Went back and saw him in another 6 weeks and the niacin did nothing for me.

Heck yes i'll try it.

My Picamilon is from Serious Nutrition Solutions

It is manufactured for distribution from Danville, Virgina.