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Efficacy of amitriptyline in the treatment of subjective tinnitus.
Bayar N, Bke B, Turan E, Belgin E.
SourceEar, Nose, and Throat Department, Faculty of Medicine, Kirikkale University, Turkey.
Abstract
We investigated the effect of amitriptyline, a tricyclic antidepressant, on patients with subjective tinnitus. The study group consisted of 37 adult patients admitted to the Ear, Nose, and Throat and Audiology Department of Hacettepe University. The amitriptyline group consisted of 20 patients and the placebo group consisted of 17 patients. All of the patients were evaluated using a questionnaire, audiologic evaluation, high-frequency audiometry, impedancemetric tests, auditory brainstem response, tinnitus frequency, and loudness matching assessed by audiometric methods at the beginning and end of the study. The patients in the amitriptyline group received 50 mg/day amitriptyline in the first week and 100 mg/day for the following 5 weeks. In the placebo group, the patients received tablets consisting of lactose starch for 6 weeks, with a dosage of 1 tablet/day. The subjective complaints of the patients in the amitriptyline group decreased, and the "present" symptoms resulted in fewer complaints. The severity of tinnitus decreased in the amitriptyline group by means of subjective and audiometric methods. In the placebo group, no significant change was observed. The success of treatment was 95% in the amitriptyline group and 12% in the placebo group. Amitriptyline therapy was concluded to be effective.
PMID:11771024[PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, SubstancesPublication TypesClinical TrialRandomized Controlled TrialMeSH TermsAdolescentAdultAmitriptyline/therapeutic use*Antidepressive Agents, Tricyclic/therapeutic use*FemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesSingle-Blind MethodTinnitus/drug therapy*Treatment OutcomeSubstancesAntidepressive Agents, TricyclicAmitriptyline
LinkOut - more resourcesFull Text SourcesEBSCOProQuest Information and LearningMedicalTinnitus - MedlinePlus Health InformationMolecular Biology DatabasesAMITRIPTYLINE - HSDB
Bayar N, Bke B, Turan E, Belgin E.
SourceEar, Nose, and Throat Department, Faculty of Medicine, Kirikkale University, Turkey.
Abstract
We investigated the effect of amitriptyline, a tricyclic antidepressant, on patients with subjective tinnitus. The study group consisted of 37 adult patients admitted to the Ear, Nose, and Throat and Audiology Department of Hacettepe University. The amitriptyline group consisted of 20 patients and the placebo group consisted of 17 patients. All of the patients were evaluated using a questionnaire, audiologic evaluation, high-frequency audiometry, impedancemetric tests, auditory brainstem response, tinnitus frequency, and loudness matching assessed by audiometric methods at the beginning and end of the study. The patients in the amitriptyline group received 50 mg/day amitriptyline in the first week and 100 mg/day for the following 5 weeks. In the placebo group, the patients received tablets consisting of lactose starch for 6 weeks, with a dosage of 1 tablet/day. The subjective complaints of the patients in the amitriptyline group decreased, and the "present" symptoms resulted in fewer complaints. The severity of tinnitus decreased in the amitriptyline group by means of subjective and audiometric methods. In the placebo group, no significant change was observed. The success of treatment was 95% in the amitriptyline group and 12% in the placebo group. Amitriptyline therapy was concluded to be effective.
PMID:11771024[PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, SubstancesPublication TypesClinical TrialRandomized Controlled TrialMeSH TermsAdolescentAdultAmitriptyline/therapeutic use*Antidepressive Agents, Tricyclic/therapeutic use*FemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesSingle-Blind MethodTinnitus/drug therapy*Treatment OutcomeSubstancesAntidepressive Agents, TricyclicAmitriptyline
LinkOut - more resourcesFull Text SourcesEBSCOProQuest Information and LearningMedicalTinnitus - MedlinePlus Health InformationMolecular Biology DatabasesAMITRIPTYLINE - HSDB
I'm giving it at least 6 weeks to see what it does. Why does anything that you try has to take at least 6 weeks to see if it helps? Anyway I have never given the Clonazepam/Gabapentin a full 6 weeks to see if it will help. If that does not work will try the higher dosage of Amitriptyline. Yet something else to at least try.
So Amitriptyline has not help you at all ?
My friend, if your don't have Tinnitus, there is a slight chance you can get it, from this drug.
But, if you already have Tinnitus, is does not make it worse.
The House Clinic in Los Angeles, one of the top hearing institutions, told me that, and they are the ones that prescribed
the medication for me, for sleep, and to lower my tinnitus
My local ENT, also gave it to me.
Read deltadart, he been using it for 10 years.
Post it if you like, get other people perspective, it works my friend.
and if you add ,25 klonopin with it, you will sleep like a baby
Delta--I had VERY quiet T at 1600mg gabap (400mg 4 times a day), 1mg Klono, and 100mg Nortryp. I got off them when I was a few months into TRT at the suggestion of my TRT audiologist.
Now I am trying Trileptal and Pramipexole twice a day (bedtime and when I wake up).
I tried nortriptyline which is the younger brother of amitriptyline and it did not help me.